Early identification of non-remission in first-episode psychosis in a two-year outcome study

TY - JOUR

T1 - Early identification of non-remission in first-episode psychosis in a two-year outcome study

AU - Simonsen, Erik

AU - Friis, S

AU - Opjordsmoen, S

AU - Mortensen, Erik Lykke

AU - Haahr, U

AU - Melle, I

AU - Joa, I

AU - Johannessen, J O

AU - Larsen, T K

AU - Røssberg, J I

AU - Rund, B R

AU - Vaglum, P

AU - McGlashan, T H

N1 - © 2010 John Wiley & Sons A/S.

PY - 2010/11

Y1 - 2010/11

N2 - Objective: To identify predictors of non-remission in first-episode, non-affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for <6 months (n = 38) and for more than 6 months (n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

AB - Objective: To identify predictors of non-remission in first-episode, non-affective psychosis. Method: During 4 years, we recruited 301 patients consecutively. Information about first remission at 3 months was available for 299 and at 2 years for 293 cases. Symptomatic and social outcomes were assessed at 3 months, 1 and 2 years. Results: One hundred and twenty-nine patients (43%) remained psychotic at 3 months and 48 patients (16.4%) remained psychotic over 2 years. When we compared premorbid and baseline data for the three groups, the non-remitted (n = 48), remitted for <6 months (n = 38) and for more than 6 months (n = 207), duration of untreated psychosis (DUP) was the only variable that significantly differentiated the groups (median DUP: 25.5, 14.4 and 6.0 weeks, respectively). Three months univariate predictors of non-remission were being single, longer DUP, core schizophrenia, and less excitative and more negative symptoms at baseline. Two-year predictors were younger age, being single and male, deteriorating premorbid social functioning, longer DUP and core schizophrenia. In multivariate analyses DUP, negative and excitative symptoms predicted non-remission at 3 months, but only DUP predicted at 2 years. Conclusion: Long DUP predicted both 3 month and 2-year non-remission rates in first-episode psychosis.

U2 - 10.1111/j.1600-0447.2010.01598.x

DO - 10.1111/j.1600-0447.2010.01598.x

M3 - Journal article

C2 - 20722632

SN - 0001-690X

VL - 122

SP - 375

EP - 383

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

IS - 5

ER -