Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme

Zitta B. Harboe; Palle Valentiner-Branth; Thomas Benfield; Jens Jørgen Christensen; Peter H. S. Andersen; Michael Howitz; Karen Angeliki Krogfelt; Lotte Lambertsen; Helle B. Konradsen

doi:10.1016/j.vaccine.2010.01.017

Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme

Zitta B. Harboe, Palle Valentiner-Branth, Thomas Benfield, Jens Jørgen Christensen, Peter H. S. Andersen, Michael Howitz, Karen Angeliki Krogfelt, Lotte Lambertsen, Helle B. Konradsen

74 Citations (Scopus)

Abstract

We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined ∼10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged ≥2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.

Original language	English
Journal	Vaccine
Volume	28
Issue number	14
Pages (from-to)	2642–2647
Number of pages	6
ISSN	0264-410X
DOIs	https://doi.org/10.1016/j.vaccine.2010.01.017
Publication status	Published - 19 Mar 2010

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Harboe, Z. B., Valentiner-Branth, P., Benfield, T., Christensen, J. J., Andersen, P. H. S., Howitz, M., Krogfelt, K. A., Lambertsen, L., & Konradsen, H. B. (2010). Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. Vaccine, 28(14), 2642–2647. https://doi.org/10.1016/j.vaccine.2010.01.017

Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme. / Harboe, Zitta B.; Valentiner-Branth, Palle; Benfield, Thomas et al.

In: Vaccine, Vol. 28, No. 14, 19.03.2010, p. 2642–2647.

Research output: Contribution to journal › Journal article › Research › peer-review

Harboe, ZB, Valentiner-Branth, P, Benfield, T , Christensen, JJ, Andersen, PHS, Howitz, M, Krogfelt, KA, Lambertsen, L & Konradsen, HB 2010, 'Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme', Vaccine, vol. 28, no. 14, pp. 2642–2647. https://doi.org/10.1016/j.vaccine.2010.01.017

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title = "Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme",

abstract = "We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined ∼10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged ≥2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.",

author = "Harboe, {Zitta B.} and Palle Valentiner-Branth and Thomas Benfield and Christensen, {Jens J{\o}rgen} and Andersen, {Peter H. S.} and Michael Howitz and Krogfelt, {Karen Angeliki} and Lotte Lambertsen and Konradsen, {Helle B.}",

note = "Keywords: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Denmark; Female; Humans; Immunization Programs; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Young Adult",

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T1 - Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme

AU - Harboe, Zitta B.

AU - Valentiner-Branth, Palle

AU - Benfield, Thomas

AU - Christensen, Jens Jørgen

AU - Andersen, Peter H. S.

AU - Howitz, Michael

AU - Krogfelt, Karen Angeliki

AU - Lambertsen, Lotte

AU - Konradsen, Helle B.

N1 - Keywords: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Denmark; Female; Humans; Immunization Programs; Incidence; Infant; Infant, Newborn; Male; Middle Aged; Pneumococcal Infections; Pneumococcal Vaccines; Young Adult

PY - 2010/3/19

Y1 - 2010/3/19

N2 - We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined ∼10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged ≥2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.

AB - We evaluated the effectiveness of the heptavalent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) 1 year after PCV7's introduction in the childhood immunization programme through a nationwide cohort study based on laboratory surveillance data. There was a decline in the overall incidence of IPD from 19.4 to 17.1 cases per 100,000 population (incidence rate ratios (IRR) 0.87; 95% confidence interval (CI) [0.81-0.96]), and of meningitis from 1.56 to 1.16 (IRR 0.74; 95% CI [0.57-0.97]) comparing pre-PCV7 (years 2000-2007) and PCV7 (year 2008) periods. In children <2 years, the incidence decreased from 54 to 23 cases per 100,000 (IRR 0.43; 95% CI [0.29-0.62]) and for vaccine-serotypes from 36.7 to 7.7 (IRR 0.20; 95% CI [0.09-0.38]). The incidence of IPD declined ∼10% (IRR 0.90; 95% CI [0.84-0.97]) in patients aged ≥2 years. The case fatality was 17% in both periods. The administration of PCV7 was followed by a marked decline in the incidence of IPD in both vaccinated and non-vaccinated individuals.

U2 - 10.1016/j.vaccine.2010.01.017

DO - 10.1016/j.vaccine.2010.01.017

M3 - Journal article

C2 - 20096392

SN - 0264-410X

VL - 28

SP - 2642

EP - 2647

JO - Vaccine

JF - Vaccine

IS - 14

ER -

Early effectiveness of heptavalent conjugate pneumococcal vaccination on invasive pneumococcal disease after the introduction in the Danish Childhood Immunization Programme

Abstract

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