Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

D E Postnov; R N Koreshkov; N A Brazhe; A R Brazhe; O V Sosnovtseva

doi:10.1007/s10867-009-9156-x

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

D E Postnov, R N Koreshkov, N A Brazhe, A R Brazhe, O V Sosnovtseva

Renal and Vascular Research

93 Citations (Scopus)

Abstract

We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

Original language	English
Journal	Journal of Biological Physics
Volume	35
Issue number	4
Pages (from-to)	425-45
Number of pages	20
ISSN	0092-0606
DOIs	https://doi.org/10.1007/s10867-009-9156-x
Publication status	Published - 2009

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title = "Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks",

abstract = "We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.",

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T1 - Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

AU - Postnov, D E

AU - Koreshkov, R N

AU - Brazhe, N A

AU - Brazhe, A R

AU - Sosnovtseva, O V

PY - 2009

Y1 - 2009

N2 - We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

AB - We propose a functional mathematical model for neuron-astrocyte networks. The model incorporates elements of the tripartite synapse and the spatial branching structure of coupled astrocytes. We consider glutamate-induced calcium signaling as a specific mode of excitability and transmission in astrocytic-neuronal networks. We reproduce local and global dynamical patterns observed experimentally.

U2 - 10.1007/s10867-009-9156-x

DO - 10.1007/s10867-009-9156-x

M3 - Journal article

C2 - 19669421

SN - 0092-0606

VL - 35

SP - 425

EP - 445

JO - Journal of Biological Physics

JF - Journal of Biological Physics

IS - 4

ER -

Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks

Abstract

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