Dynamic modeling of renal blood flow in Dahl hypertensive and normotensive rats.

Torben Knudsen; Henrik Elmer; Morten H Knudsen; Jakob Stoustrup; N.-H. Holstein-Rathlou

doi:10.1109/TBME.2004.826593

Dynamic modeling of renal blood flow in Dahl hypertensive and normotensive rats.

Torben Knudsen, Henrik Elmer, Morten H Knudsen, Jakob Stoustrup, N.-H. Holstein-Rathlou

Department of Biomedical Sciences

9 Citations (Scopus)

Abstract

A method is proposed in this paper which allows characterization of renal autoregulatory dynamics and efficiency using quantitative mathematical methods. Based on data from rat experiments, where arterial blood pressure and renal blood flow are measured, a quantitative model for renal blood flow dynamics is constructed. The mathematical structure for the dynamics is chosen as a "grey-box model," i.e. the model structure is inspired from physiology, but the actual parameters is found by numerical methods. Based on a number of experiments, features are extracted from the estimated parameters, which describe myogenic responses and tubuloglomerular feedback responses separately. The method is applied to data from normo- and hypertensive Dahl rats, and a discriminator that separates data from normotensive Dahl R rats and hypertensive Dahl S rats is constructed.

Original language	English
Journal	IEEE Transactions on Biomedical Engineering
Volume	51
Issue number	5
Pages (from-to)	689-97
Number of pages	8
ISSN	0018-9294
DOIs	https://doi.org/10.1109/TBME.2004.826593
Publication status	Published - 2004

Access to Document

10.1109/TBME.2004.826593

Cite this

@article{74550810ab6111ddb5e9000ea68e967b,

title = "Dynamic modeling of renal blood flow in Dahl hypertensive and normotensive rats.",

abstract = "A method is proposed in this paper which allows characterization of renal autoregulatory dynamics and efficiency using quantitative mathematical methods. Based on data from rat experiments, where arterial blood pressure and renal blood flow are measured, a quantitative model for renal blood flow dynamics is constructed. The mathematical structure for the dynamics is chosen as a {"}grey-box model,{"} i.e. the model structure is inspired from physiology, but the actual parameters is found by numerical methods. Based on a number of experiments, features are extracted from the estimated parameters, which describe myogenic responses and tubuloglomerular feedback responses separately. The method is applied to data from normo- and hypertensive Dahl rats, and a discriminator that separates data from normotensive Dahl R rats and hypertensive Dahl S rats is constructed.",

author = "Torben Knudsen and Henrik Elmer and Knudsen, {Morten H} and Jakob Stoustrup and N.-H. Holstein-Rathlou",

note = "Keywords: Adaptation, Physiological; Animals; Blood Flow Velocity; Blood Pressure; Computer Simulation; Diagnosis, Computer-Assisted; Feedback; Hemostasis; Hypertension, Renal; Kidney; Male; Models, Cardiovascular; Rats; Rats, Inbred Dahl; Reference Values; Renal Artery; Renal Circulation; Reproducibility of Results; Sensitivity and Specificity",

year = "2004",

doi = "10.1109/TBME.2004.826593",

language = "English",

volume = "51",

pages = "689--97",

journal = "IEEE Transactions on Biomedical Engineering",

issn = "0018-9294",

publisher = "Institute of Electrical and Electronics Engineers",

number = "5",

}

TY - JOUR

T1 - Dynamic modeling of renal blood flow in Dahl hypertensive and normotensive rats.

AU - Knudsen, Torben

AU - Elmer, Henrik

AU - Knudsen, Morten H

AU - Stoustrup, Jakob

AU - Holstein-Rathlou, N.-H.

N1 - Keywords: Adaptation, Physiological; Animals; Blood Flow Velocity; Blood Pressure; Computer Simulation; Diagnosis, Computer-Assisted; Feedback; Hemostasis; Hypertension, Renal; Kidney; Male; Models, Cardiovascular; Rats; Rats, Inbred Dahl; Reference Values; Renal Artery; Renal Circulation; Reproducibility of Results; Sensitivity and Specificity

PY - 2004

Y1 - 2004

N2 - A method is proposed in this paper which allows characterization of renal autoregulatory dynamics and efficiency using quantitative mathematical methods. Based on data from rat experiments, where arterial blood pressure and renal blood flow are measured, a quantitative model for renal blood flow dynamics is constructed. The mathematical structure for the dynamics is chosen as a "grey-box model," i.e. the model structure is inspired from physiology, but the actual parameters is found by numerical methods. Based on a number of experiments, features are extracted from the estimated parameters, which describe myogenic responses and tubuloglomerular feedback responses separately. The method is applied to data from normo- and hypertensive Dahl rats, and a discriminator that separates data from normotensive Dahl R rats and hypertensive Dahl S rats is constructed.

AB - A method is proposed in this paper which allows characterization of renal autoregulatory dynamics and efficiency using quantitative mathematical methods. Based on data from rat experiments, where arterial blood pressure and renal blood flow are measured, a quantitative model for renal blood flow dynamics is constructed. The mathematical structure for the dynamics is chosen as a "grey-box model," i.e. the model structure is inspired from physiology, but the actual parameters is found by numerical methods. Based on a number of experiments, features are extracted from the estimated parameters, which describe myogenic responses and tubuloglomerular feedback responses separately. The method is applied to data from normo- and hypertensive Dahl rats, and a discriminator that separates data from normotensive Dahl R rats and hypertensive Dahl S rats is constructed.

U2 - 10.1109/TBME.2004.826593

DO - 10.1109/TBME.2004.826593

M3 - Journal article

C2 - 15132494

SN - 0018-9294

VL - 51

SP - 689

EP - 697

JO - IEEE Transactions on Biomedical Engineering

JF - IEEE Transactions on Biomedical Engineering

IS - 5

ER -

Dynamic modeling of renal blood flow in Dahl hypertensive and normotensive rats.

Abstract

Access to Document

Fingerprint

Cite this