Dynamic adaptation of tendon and muscle connective tissue to mechanical loading

TY - JOUR

T1 - Dynamic adaptation of tendon and muscle connective tissue to mechanical loading

AU - Mackey, Abigail

AU - Heinemeier, Katja Maria

AU - Koskinen, Satu Osmi Anneli

AU - Kjaer, Michael

N1 - Keywords: Adaptation, Physiological; Animals; Collagen; Connective Tissue; Extracellular Matrix; Female; Fibroblasts; Humans; Intercellular Signaling Peptides and Proteins; Male; Matrix Metalloproteinase 14; Muscle, Skeletal; Sex Characteristics; Stress, Mechanical; Tendons

PY - 2008

Y1 - 2008

N2 - The connective tissue of tendon and skeletal muscle is a crucial structure for force transmission. A dynamic adaptive capacity of these tissues in healthy individuals is evident from reports of altered gene expression and protein levels of the fibrillar and network-forming collagens, when subjected to mechanical loading. While it appears that the fibroblast is a key player in sensing and responding to loading, the issue of how these signals are converted into changed gene expression is not fully understood. It is clear, however, that the loading-induced response involves a variety of growth factors, in particular TGF-beta-1, and matrix remodelling enzymes such as MMP-2. Furthermore, it is under hormonal influence. In skeletal muscle, the extracellular matrix demonstrates its potential for cross-talk by regulating the activity of cells with which it is in contact. Taken together, the studies highlighted in this article provide strong evidence for the highly adaptable nature of connective tissue in muscle and tendon.

AB - The connective tissue of tendon and skeletal muscle is a crucial structure for force transmission. A dynamic adaptive capacity of these tissues in healthy individuals is evident from reports of altered gene expression and protein levels of the fibrillar and network-forming collagens, when subjected to mechanical loading. While it appears that the fibroblast is a key player in sensing and responding to loading, the issue of how these signals are converted into changed gene expression is not fully understood. It is clear, however, that the loading-induced response involves a variety of growth factors, in particular TGF-beta-1, and matrix remodelling enzymes such as MMP-2. Furthermore, it is under hormonal influence. In skeletal muscle, the extracellular matrix demonstrates its potential for cross-talk by regulating the activity of cells with which it is in contact. Taken together, the studies highlighted in this article provide strong evidence for the highly adaptable nature of connective tissue in muscle and tendon.

U2 - 10.1080/03008200802151672

DO - 10.1080/03008200802151672

M3 - Journal article

C2 - 18661335

SN - 0300-8207

VL - 49

SP - 165

EP - 168

JO - Connective Tissue Research

JF - Connective Tissue Research

IS - 3

ER -