Drug nanocrystallisation within liposomes

Tang Li; David Cipolla; Thomas Rades; Ben J. Boyd

doi:10.1016/j.jconrel.2018.09.001

Drug nanocrystallisation within liposomes

Tang Li, David Cipolla, Thomas Rades, Ben J. Boyd^*

^*Corresponding author for this work

41 Citations (Scopus)

Abstract

Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.

Original language	English
Journal	Journal of Controlled Release
Volume	288
Pages (from-to)	96-110
Number of pages	15
ISSN	0168-3659
DOIs	https://doi.org/10.1016/j.jconrel.2018.09.001
Publication status	Published - 2018

Keywords

Liposomes
Nanocrystal
Polymorph
Precipitation
Solid state

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10.1016/j.jconrel.2018.09.001

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title = "Drug nanocrystallisation within liposomes",

abstract = "Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.",

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AU - Li, Tang

AU - Cipolla, David

AU - Rades, Thomas

AU - Boyd, Ben J.

PY - 2018

Y1 - 2018

N2 - Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.

AB - Liposomes are phospholipid bilayer vesicles that have been explored in pharmaceutical research as drug delivery systems for >50 years. Despite being important to their morphology and drug release pattern, the physical state of the drug within liposomes (liquid, solid, crystalline form) is often overlooked. This review focuses on precipitation of drug within liposomes, which can result in the formation of confined nanocrystals, and consequent changes in liposome morphology and drug release patterns. The type of drugs that form nanocrystals within liposomes, preparation and characterisation of liposomal drug nanocrystals, and the in vitro drug release behaviour from these systems are communicated, with a discussion of their potential as drug delivery systems.

KW - Liposomes

KW - Nanocrystal

KW - Polymorph

KW - Precipitation

KW - Solid state

U2 - 10.1016/j.jconrel.2018.09.001

DO - 10.1016/j.jconrel.2018.09.001

M3 - Review

C2 - 30184465

AN - SCOPUS:85052954296

SN - 0168-3659

VL - 288

SP - 96

EP - 110

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Drug nanocrystallisation within liposomes

Abstract

Keywords

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