Abstract
The Danish Committee on Adverse Drug Reactions received 1100 reports of suspected drug-induced hepatic injury during the decade 1978-1987. The causal relationship between drug and hepatic injury was classified as definite in 57 (5.2%) reports, probable in 989 (89.9%) reports, possible in 50 (4.5%) reports and unclassifiable in four (0.4%) reports. Hepatic injuries accounted for 5.9% of all adverse drug reactions reported, and 14.7% of the lethal adverse drug reactions. A total of 47.2% were classified as acute cytotoxic, 16.2% as acute cholestatic and 26.9% as abnormal hepatic function. In 52 (4.7%) cases the hepatic injury was lethal; only 14 (1.3%) cases were chronic. Halothane accounted for 25% of the cases. The incidence of halothane-induced hepatic injury is decreasing, and only one lethal case has been reported since 1981. Next to halothane, sulfasalazine was the drug most often suspected during the last 2 years of the decade. Based on consumption data, the incidence of hepatic injury due to sulindac was estimated to be 18-fold higher than that due to ibuprofen. Paracetamol was reported to induce acute cytotoxic as well as cholestatic reactions in non-alcoholic subjects taking therapeutic doses.
| Original language | English |
|---|---|
| Journal | Journal of Internal Medicine |
| Volume | 232 |
| Issue number | 2 |
| Pages (from-to) | 133-138 |
| Number of pages | 6 |
| ISSN | 0954-6820 |
| Publication status | Published - Aug 1992 |
Keywords
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alkaline Phosphatase
- Child
- Child, Preschool
- Clinical Enzyme Tests
- Denmark
- Drug-Induced Liver Injury
- Female
- Humans
- Infant
- Liver Diseases
- Liver Function Tests
- Male
- Middle Aged
- Transaminases