Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease

TY - JOUR

T1 - Dopamine replacement modulates oscillatory coupling between premotor and motor cortical areas in Parkinson's disease

AU - Herz, Damian Marc

AU - Florin, Esther

AU - Christensen, Mark Schram

AU - Reck, Christiane

AU - Barbe, Michael Thomas

AU - Tscheuschler, Maike Karoline

AU - Tittgemeyer, Marc

AU - Siebner, Hartwig Roman

AU - Timmermann, Lars

N1 - CURIS 2014 NEXS 313

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.

AB - Efficient neural communication between premotor and motor cortical areas is critical for manual motor control. Here, we used high-density electroencephalography to study cortical connectivity in patients with Parkinson's disease (PD) and age-matched healthy controls while they performed repetitive movements of the right index finger at maximal repetition rate. Multiple source beamformer analysis and dynamic causal modeling were used to assess oscillatory coupling between the lateral premotor cortex (lPM), supplementary motor area (SMA), and primary motor cortex (M1) in the contralateral hemisphere. Elderly healthy controls showed task-related modulation in connections from lPM to SMA and M1, mainly within the γ-band (>30 Hz). Nonmedicated PD patients also showed task-related γ-γ coupling from lPM to M1, but γ coupling from lPM to SMA was absent. Levodopa reinstated physiological γ-γ coupling from lPM to SMA and significantly strengthened coupling in the feedback connection from M1 to lPM expressed as β-β as well as θ-β coupling. Enhancement in cross-frequency θ-β coupling from M1 to lPM was correlated with levodopa-induced improvement in motor function. The results show that PD is associated with an altered neural communication between premotor and motor cortical areas, which can be modulated by dopamine replacement.

U2 - 10.1093/cercor/bht140

DO - 10.1093/cercor/bht140

M3 - Journal article

C2 - 23733911

SN - 1047-3211

VL - 24

SP - 2873

EP - 2883

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 11

ER -