Dopamine, dobutamine, and dopexamine. A comparison of renal effects in unanesthetized human volunteers

TY - JOUR

T1 - Dopamine, dobutamine, and dopexamine. A comparison of renal effects in unanesthetized human volunteers

AU - Olsen, Niels Vidiendal

AU - Lund, J

AU - Jensen, P F

AU - Espersen, K

AU - Kanstrup, I L

AU - Plum, I

AU - Leyssac, P P

PY - 1993/10

Y1 - 1993/10

N2 - Recently, dopexamine (DX), which acts via adrenergic beta 2 and dopaminergic DA1 receptors, has been introduced in the treatment of low cardiac output states. However, the renal effects of DX have not been compared to those produced by equipotent inotropic doses of dopamine (DA), which predominantly stimulates DA1 and DA2 receptors, and of dobutamine (DB), which stimulates beta 1 but not DA receptors. The current study tested the null hypothesis that, with equal increases in cardiac output, DX, DA, and DB would have similar effects on renal function.

AB - Recently, dopexamine (DX), which acts via adrenergic beta 2 and dopaminergic DA1 receptors, has been introduced in the treatment of low cardiac output states. However, the renal effects of DX have not been compared to those produced by equipotent inotropic doses of dopamine (DA), which predominantly stimulates DA1 and DA2 receptors, and of dobutamine (DB), which stimulates beta 1 but not DA receptors. The current study tested the null hypothesis that, with equal increases in cardiac output, DX, DA, and DB would have similar effects on renal function.

KW - Adult

KW - Aldosterone

KW - Anesthesia

KW - Cardiac Output

KW - Dobutamine

KW - Dopamine

KW - Dopamine Agents

KW - Dose-Response Relationship, Drug

KW - Glomerular Filtration Rate

KW - Hemodynamics

KW - Humans

KW - Kidney

KW - Kidney Tubules

KW - Male

KW - Renin

KW - Sodium

KW - Stimulation, Chemical

KW - Water

M3 - Journal article

C2 - 8105728

SN - 0003-3022

VL - 79

SP - 685

EP - 694

JO - Anesthesiology

JF - Anesthesiology

IS - 4

ER -