Does S100B have a potential role in affective disorders? A literature review

TY - JOUR

T1 - Does S100B have a potential role in affective disorders?

T2 - A literature review

AU - Kroksmark, Hilda

AU - Vinberg, Maj

PY - 2018/10/3

Y1 - 2018/10/3

N2 - BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders.AIM: To review the literature investigating the role of S100B in patients with affective disorders.METHOD: A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database. Effect sizes were calculated to adjust for systematic measurement effects.RESULTS: Twenty studies were included, with a total of 1292 participants. Of these, 398 patients had or have had depressive disorder, 301 patients had bipolar disorder and 593 were healthy controls. S100B levels in serum were consistently elevated in studies with statistically significant results which investigated acute affective episodes (comprising major depressive episode in major depressive disorder, and both manic and depressive episodes in patients with bipolar disorder), in comparison to healthy controls. There were few studies assessing S100B levels in cerebrospinal fluid, plasma or lymphocytes, and these had inconsistent results.CONCLUSION: The results indicated that elevated S100B levels might be associated with mood episodes in affective disorders. However, the role of S100B, and its possible impact in affective disorders, requires further investigation and at the present S100B does not have a role as clinically biomarker in affective disorder. Future longitudinal multicentre studies with larger transdiagnostic real life patient cohorts are warranted.

AB - BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders.AIM: To review the literature investigating the role of S100B in patients with affective disorders.METHOD: A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database. Effect sizes were calculated to adjust for systematic measurement effects.RESULTS: Twenty studies were included, with a total of 1292 participants. Of these, 398 patients had or have had depressive disorder, 301 patients had bipolar disorder and 593 were healthy controls. S100B levels in serum were consistently elevated in studies with statistically significant results which investigated acute affective episodes (comprising major depressive episode in major depressive disorder, and both manic and depressive episodes in patients with bipolar disorder), in comparison to healthy controls. There were few studies assessing S100B levels in cerebrospinal fluid, plasma or lymphocytes, and these had inconsistent results.CONCLUSION: The results indicated that elevated S100B levels might be associated with mood episodes in affective disorders. However, the role of S100B, and its possible impact in affective disorders, requires further investigation and at the present S100B does not have a role as clinically biomarker in affective disorder. Future longitudinal multicentre studies with larger transdiagnostic real life patient cohorts are warranted.

KW - Adult

KW - Biomarkers/blood

KW - Bipolar Disorder/blood

KW - Depressive Disorder, Major/blood

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Mood Disorders/blood

KW - S100 Calcium Binding Protein beta Subunit/blood

U2 - 10.1080/08039488.2018.1472295

DO - 10.1080/08039488.2018.1472295

M3 - Review

C2 - 29764272

SN - 0803-9488

VL - 72

SP - 462

EP - 470

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

IS - 7

ER -