Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

TY - JOUR

T1 - Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy?

AU - Hartoft-Nielsen, Marie-Louise

AU - Boas, Malene

AU - Bliddal, Sofie

AU - Rasmussen, Aase Krogh

AU - Main, Katharina

AU - Feldt-Rasmussen, Ulla

PY - 2011

Y1 - 2011

N2 - Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals-endocrine disrupting chemicals (EDCs)-has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce.

AB - Maternal euthyroidism during pregnancy is crucial for normal development and, in particular, neurodevelopment of the foetus. Up to 3.5 percent of pregnant women suffer from hypothyroidism. Industrial use of various chemicals-endocrine disrupting chemicals (EDCs)-has been shown to cause almost constant exposure of humans with possible harmful influence on health and hormone regulation. EDCs may affect thyroid hormone homeostasis by different mechanisms, and though the effect of each chemical seems scarce, the added effects may cause inappropriate consequences on, for example, foetal neurodevelopment. This paper focuses on thyroid hormone influence on foetal development in relation to the chemicals suspected of thyroid disrupting properties with possible interactions with maternal thyroid homeostasis. Knowledge of the effects is expected to impact the general debate on the use of these chemicals. However, more studies are needed to elucidate the issue, since human studies are scarce.

U2 - http://dx.doi.org/10.4061/2011/342189

DO - http://dx.doi.org/10.4061/2011/342189

M3 - Journal article

SN - 2090-8067

VL - 2011

SP - 342189

JO - Journal of Thyroid Research

JF - Journal of Thyroid Research

ER -