DNA methylation in metabolic disorders

Romain Barres; Juleen R Zierath

doi:10.3945/ajcn.110.001933

DNA methylation in metabolic disorders

100 Citations (Scopus)

Abstract

DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.

Original language	English
Journal	American Journal of Clinical Nutrition
Volume	93
Issue number	4
Pages (from-to)	897S-900
ISSN	0002-9165
DOIs	https://doi.org/10.3945/ajcn.110.001933
Publication status	Published - 1 Apr 2011

Keywords

DNA Methylation
Diet
Environment
Epigenesis, Genetic
Exercise
Gene Expression
Genetic Predisposition to Disease
Humans
Metabolic Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3945/ajcn.110.001933

https://academic.oup.com/ajcn/article-pdf/93/4/897S/23871499/897s.pdf

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title = "DNA methylation in metabolic disorders",

abstract = "DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.",

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AU - Barres, Romain

AU - Zierath, Juleen R

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AB - DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.

KW - DNA Methylation

KW - Diet

KW - Environment

KW - Epigenesis, Genetic

KW - Exercise

KW - Gene Expression

KW - Genetic Predisposition to Disease

KW - Humans

KW - Metabolic Diseases

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DO - 10.3945/ajcn.110.001933

M3 - Review

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VL - 93

SP - 897S-900

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 4

ER -

DNA methylation in metabolic disorders

Abstract

Keywords

UN SDGs

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