Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr

Marie Louise Max Andersen; Lotte B Nielsen; Jannet Svensson; Sven Pörksen; Philip Hougaard; Craig Beam; Carla Greenbaum; Dorothy Becker; Jacob S Petersen; Lars Hansen; Henrik B Mortensen

doi:10.1111/pedi.12098

Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr

Marie Louise Max Andersen, Lotte B Nielsen, Jannet Svensson, Sven Pörksen, Philip Hougaard, Craig Beam, Carla Greenbaum, Dorothy Becker, Jacob S Petersen, Lars Hansen, Henrik B Mortensen

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

Objective: To clarify whether the rate of decline in stimulated C-peptide (SCP) from 2 to 15months after diagnosis has changed over an interval of 27yr. Research design and methods: The rate of decline in SCP levels at 1, 2, 3, 6, 9, 12, and 15months after diagnosis was compared in four paediatric cohorts from Scandinavian and European countries including 446 children with new onset type 1 diabetes (T1D, 1982-2004). Findings were evaluated against 78 children (2004-2009) from the TrialNet studies. Results: The mean rate of decline [%/month (±SEM)] in SCP for a 10-yr-old child was 7.7%/month (±1.5) in the 1982-1985 Cohort, 6.3%/month (±1.7) in the 1995-1998 Cohort, 7.8%/month (±0.7) in the 1999-2000 Cohort, and 10.7%/month (±0.9) in the latest 2004-2005 Cohort (p=0.05). Including the TrialNet Cohort with a rate of decline in SCP of 10.0%/month (±0.9) the differences between the cohorts are still significant (p=0.039). The rate of decline in SCP was negatively associated with age (p<0.0001), insulin antibodies (IA) (p=0.003), and glutamic acid decarboxylase-65 (GAD65A) (p=0.03) initially with no statistically significant effect of body mass index (BMI) Z-score at 3months. Also, at 3months the time around partial remission, the effect of age on SCP was significantly greater in children ≤5yr compared with older children (p≤0.0001). Conclusions: During the past 27yr, initial C-peptide as well as the rate of C-peptide decline seem to have increased. The rate of decline was affected significantly by age, GAD65A, and IA, but not BMI Z-score or initial C-peptide.

Original language	English
Journal	Pediatric Diabetes
Volume	15
Issue number	5
Pages (from-to)	345-354
Number of pages	10
ISSN	1399-543X
DOIs	https://doi.org/10.1111/pedi.12098
Publication status	Published - Aug 2014

Keywords

Body Mass Index
C-Peptide
Child
Child, Preschool
Cohort Studies
Diabetes Mellitus, Type 1
Disease Progression
Europe
European Continental Ancestry Group
Female
Glutamate Decarboxylase
Humans
Infant
Insulin Antibodies
Male
North America
Scandinavian and Nordic Countries

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/pedi.12098

Cite this

Andersen, M. L. M., Nielsen, L. B., Svensson, J., Pörksen, S., Hougaard, P., Beam, C., Greenbaum, C., Becker, D., Petersen, J. S., Hansen, L., & Mortensen, H. B. (2014). Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr. Pediatric Diabetes, 15(5), 345-354. https://doi.org/10.1111/pedi.12098

Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr. / Andersen, Marie Louise Max; Nielsen, Lotte B; Svensson, Jannet et al.
In: Pediatric Diabetes, Vol. 15, No. 5, 08.2014, p. 345-354.

Research output: Contribution to journal › Journal article › Research › peer-review

Andersen, MLM, Nielsen, LB, Svensson, J, Pörksen, S, Hougaard, P, Beam, C, Greenbaum, C, Becker, D, Petersen, JS, Hansen, L & Mortensen, HB 2014, 'Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr', Pediatric Diabetes, vol. 15, no. 5, pp. 345-354. https://doi.org/10.1111/pedi.12098

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title = "Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr",

abstract = "Objective: To clarify whether the rate of decline in stimulated C-peptide (SCP) from 2 to 15months after diagnosis has changed over an interval of 27yr. Research design and methods: The rate of decline in SCP levels at 1, 2, 3, 6, 9, 12, and 15months after diagnosis was compared in four paediatric cohorts from Scandinavian and European countries including 446 children with new onset type 1 diabetes (T1D, 1982-2004). Findings were evaluated against 78 children (2004-2009) from the TrialNet studies. Results: The mean rate of decline [%/month (±SEM)] in SCP for a 10-yr-old child was 7.7%/month (±1.5) in the 1982-1985 Cohort, 6.3%/month (±1.7) in the 1995-1998 Cohort, 7.8%/month (±0.7) in the 1999-2000 Cohort, and 10.7%/month (±0.9) in the latest 2004-2005 Cohort (p=0.05). Including the TrialNet Cohort with a rate of decline in SCP of 10.0%/month (±0.9) the differences between the cohorts are still significant (p=0.039). The rate of decline in SCP was negatively associated with age (p<0.0001), insulin antibodies (IA) (p=0.003), and glutamic acid decarboxylase-65 (GAD65A) (p=0.03) initially with no statistically significant effect of body mass index (BMI) Z-score at 3months. Also, at 3months the time around partial remission, the effect of age on SCP was significantly greater in children ≤5yr compared with older children (p≤0.0001). Conclusions: During the past 27yr, initial C-peptide as well as the rate of C-peptide decline seem to have increased. The rate of decline was affected significantly by age, GAD65A, and IA, but not BMI Z-score or initial C-peptide.",

keywords = "Body Mass Index, C-Peptide, Child, Child, Preschool, Cohort Studies, Diabetes Mellitus, Type 1, Disease Progression, Europe, European Continental Ancestry Group, Female, Glutamate Decarboxylase, Humans, Infant, Insulin Antibodies, Male, North America, Scandinavian and Nordic Countries",

author = "Andersen, {Marie Louise Max} and Nielsen, {Lotte B} and Jannet Svensson and Sven P{\"o}rksen and Philip Hougaard and Craig Beam and Carla Greenbaum and Dorothy Becker and Petersen, {Jacob S} and Lars Hansen and Mortensen, {Henrik B}",

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year = "2014",

month = aug,

doi = "10.1111/pedi.12098",

language = "English",

volume = "15",

pages = "345--354",

journal = "Pediatric Diabetes",

issn = "1399-543X",

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TY - JOUR

T1 - Disease progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North America during the last 27 yr

AU - Andersen, Marie Louise Max

AU - Nielsen, Lotte B

AU - Svensson, Jannet

AU - Pörksen, Sven

AU - Hougaard, Philip

AU - Beam, Craig

AU - Greenbaum, Carla

AU - Becker, Dorothy

AU - Petersen, Jacob S

AU - Hansen, Lars

AU - Mortensen, Henrik B

PY - 2014/8

Y1 - 2014/8

N2 - Objective: To clarify whether the rate of decline in stimulated C-peptide (SCP) from 2 to 15months after diagnosis has changed over an interval of 27yr. Research design and methods: The rate of decline in SCP levels at 1, 2, 3, 6, 9, 12, and 15months after diagnosis was compared in four paediatric cohorts from Scandinavian and European countries including 446 children with new onset type 1 diabetes (T1D, 1982-2004). Findings were evaluated against 78 children (2004-2009) from the TrialNet studies. Results: The mean rate of decline [%/month (±SEM)] in SCP for a 10-yr-old child was 7.7%/month (±1.5) in the 1982-1985 Cohort, 6.3%/month (±1.7) in the 1995-1998 Cohort, 7.8%/month (±0.7) in the 1999-2000 Cohort, and 10.7%/month (±0.9) in the latest 2004-2005 Cohort (p=0.05). Including the TrialNet Cohort with a rate of decline in SCP of 10.0%/month (±0.9) the differences between the cohorts are still significant (p=0.039). The rate of decline in SCP was negatively associated with age (p<0.0001), insulin antibodies (IA) (p=0.003), and glutamic acid decarboxylase-65 (GAD65A) (p=0.03) initially with no statistically significant effect of body mass index (BMI) Z-score at 3months. Also, at 3months the time around partial remission, the effect of age on SCP was significantly greater in children ≤5yr compared with older children (p≤0.0001). Conclusions: During the past 27yr, initial C-peptide as well as the rate of C-peptide decline seem to have increased. The rate of decline was affected significantly by age, GAD65A, and IA, but not BMI Z-score or initial C-peptide.

AB - Objective: To clarify whether the rate of decline in stimulated C-peptide (SCP) from 2 to 15months after diagnosis has changed over an interval of 27yr. Research design and methods: The rate of decline in SCP levels at 1, 2, 3, 6, 9, 12, and 15months after diagnosis was compared in four paediatric cohorts from Scandinavian and European countries including 446 children with new onset type 1 diabetes (T1D, 1982-2004). Findings were evaluated against 78 children (2004-2009) from the TrialNet studies. Results: The mean rate of decline [%/month (±SEM)] in SCP for a 10-yr-old child was 7.7%/month (±1.5) in the 1982-1985 Cohort, 6.3%/month (±1.7) in the 1995-1998 Cohort, 7.8%/month (±0.7) in the 1999-2000 Cohort, and 10.7%/month (±0.9) in the latest 2004-2005 Cohort (p=0.05). Including the TrialNet Cohort with a rate of decline in SCP of 10.0%/month (±0.9) the differences between the cohorts are still significant (p=0.039). The rate of decline in SCP was negatively associated with age (p<0.0001), insulin antibodies (IA) (p=0.003), and glutamic acid decarboxylase-65 (GAD65A) (p=0.03) initially with no statistically significant effect of body mass index (BMI) Z-score at 3months. Also, at 3months the time around partial remission, the effect of age on SCP was significantly greater in children ≤5yr compared with older children (p≤0.0001). Conclusions: During the past 27yr, initial C-peptide as well as the rate of C-peptide decline seem to have increased. The rate of decline was affected significantly by age, GAD65A, and IA, but not BMI Z-score or initial C-peptide.

KW - Body Mass Index

KW - C-Peptide

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Diabetes Mellitus, Type 1

KW - Disease Progression

KW - Europe

KW - European Continental Ancestry Group

KW - Female

KW - Glutamate Decarboxylase

KW - Humans

KW - Infant

KW - Insulin Antibodies

KW - Male

KW - North America

KW - Scandinavian and Nordic Countries

U2 - 10.1111/pedi.12098

DO - 10.1111/pedi.12098

M3 - Journal article

C2 - 24731251

SN - 1399-543X

VL - 15

SP - 345

EP - 354

JO - Pediatric Diabetes

JF - Pediatric Diabetes

IS - 5