Direct N9-arylation of purines with aryl halides

Anders Foller Larsen; Trond Ulven

doi:10.1039/c3cc48642g

Direct N9-arylation of purines with aryl halides

Anders Foller Larsen, Trond Ulven

15 Citations (Scopus)

Abstract

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.

Original language	English
Journal	Chemical Communications
Volume	50
Issue number	39
Pages (from-to)	4997-4999
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c3cc48642g
Publication status	Published - 17 Apr 2014
Externally published	Yes

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title = "Direct N9-arylation of purines with aryl halides",

abstract = "An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.",

author = "Larsen, {Anders Foller} and Trond Ulven",

year = "2014",

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doi = "10.1039/c3cc48642g",

language = "English",

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publisher = "Royal Society of Chemistry",

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T1 - Direct N9-arylation of purines with aryl halides

AU - Larsen, Anders Foller

AU - Ulven, Trond

PY - 2014/4/17

Y1 - 2014/4/17

N2 - An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.

AB - An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.

U2 - 10.1039/c3cc48642g

DO - 10.1039/c3cc48642g

M3 - Journal article

SN - 1359-7345

VL - 50

SP - 4997

EP - 4999

JO - Chemical Communications

JF - Chemical Communications

IS - 39

ER -

Direct N9-arylation of purines with aryl halides

Abstract

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