Direct action of endocrine disrupting chemicals on human sperm

Christian Schiffer; Astrid Müller; Dorte L Egeberg; Luis Alvarez; Christoph Brenker; Anders Aagaard Rehfeld; Hanne Frederiksen; Benjamin Wäschle; U Benjamin Kaupp; Melanie Balbach; Dagmar Wachten; Niels E Skakkebaek; Kristian Almstrup; Timo Strünker

doi:10.15252/embr.201438869

Direct action of endocrine disrupting chemicals on human sperm

Christian Schiffer, Astrid Müller, Dorte L Egeberg, Luis Alvarez, Christoph Brenker, Anders Aagaard Rehfeld, Hanne Frederiksen, Benjamin Wäschle, U Benjamin Kaupp, Melanie Balbach, Dagmar Wachten, Niels E Skakkebaek, Kristian Almstrup, Timo Strünker

90 Citations (Scopus)

Abstract

Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

Original language	English
Journal	E M B O Reports
Volume	15
Issue number	7
Pages (from-to)	758-65
Number of pages	8
ISSN	1469-221X
DOIs	https://doi.org/10.15252/embr.201438869
Publication status	Published - Jul 2014
Externally published	Yes

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title = "Direct action of endocrine disrupting chemicals on human sperm",

abstract = "Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.",

author = "Christian Schiffer and Astrid M{\"u}ller and Egeberg, {Dorte L} and Luis Alvarez and Christoph Brenker and Rehfeld, {Anders Aagaard} and Hanne Frederiksen and Benjamin W{\"a}schle and Kaupp, {U Benjamin} and Melanie Balbach and Dagmar Wachten and Skakkebaek, {Niels E} and Kristian Almstrup and Timo Str{\"u}nker",

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year = "2014",

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doi = "10.15252/embr.201438869",

language = "English",

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pages = "758--65",

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TY - JOUR

T1 - Direct action of endocrine disrupting chemicals on human sperm

AU - Schiffer, Christian

AU - Müller, Astrid

AU - Egeberg, Dorte L

AU - Alvarez, Luis

AU - Brenker, Christoph

AU - Rehfeld, Anders Aagaard

AU - Frederiksen, Hanne

AU - Wäschle, Benjamin

AU - Kaupp, U Benjamin

AU - Balbach, Melanie

AU - Wachten, Dagmar

AU - Skakkebaek, Niels E

AU - Almstrup, Kristian

AU - Strünker, Timo

PY - 2014/7

Y1 - 2014/7

N2 - Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

AB - Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm-specific CatSper channel and, thereby, evoke an intracellular Ca(2+) increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low-dose mixtures to elevate Ca(2+) levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.

U2 - 10.15252/embr.201438869

DO - 10.15252/embr.201438869

M3 - Journal article

C2 - 24820036

SN - 1469-221X

VL - 15

SP - 758

EP - 765

JO - E M B O Reports

JF - E M B O Reports

IS - 7

ER -

Direct action of endocrine disrupting chemicals on human sperm

Abstract

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