Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

TY - JOUR

T1 - Differences in the dietary requirement for vitamin D among Caucasian and East African women at Northern latitude

AU - Cashman, Kevin D

AU - Ritz, Christian

AU - Adebayo, Folasade A

AU - Dowling, Kirsten G

AU - Itkonen, Suvi T

AU - Öhman, Taina

AU - Skaffari, Essi

AU - Saarnio, Elisa M

AU - Kiely, Mairead

AU - Allardt, Christel Lamberg

N1 - CURIS 2019 NEXS 267

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Context: Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities. Objective: To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations ≥ 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude. Methods: We used data from a 5-month, winter-based, vitamin D3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21–64-year old, living in Southern Finland (60°N), to model the vitamin D intake–serum 25(OH)D dose–response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L. Results: Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D ≥ 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 µg/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds. Conclusion: The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose–response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

AB - Context: Current vitamin D recommendations have been established based on an assumption that there are no differences between Caucasian and other ethnic/racial groups in terms of vitamin D requirements. This assumption, largely made due to the absence of data, is a key knowledge gap identified by a number of authorities. Objective: To test whether the distribution of dietary requirements for maintaining winter serum 25-hydroxyvitamin D [25(OH)D] concentrations ≥ 30 nmol/L (a priority threshold linked to vitamin D deficiency prevention) differ between Caucasian and Somali women living at northerly latitude. Methods: We used data from a 5-month, winter-based, vitamin D3 dose-related randomized, placebo-controlled trial in Somali (n 47) and Causcian women (n 69), aged 21–64-year old, living in Southern Finland (60°N), to model the vitamin D intake–serum 25(OH)D dose–response relationship. Regression analyses were used to predict the vitamin D intake required to maintain 97.5% (as well as 50, 90, and 95%) of women in both ethnic groups above serum 25(OH)D thresholds of 30, 40 and 50 nmol/L. Results: Using a model which adjusted for baseline 25(OH)D, age, and BMI, the estimated vitamin D intake that maintained serum 25(OH)D ≥ 30 nmol/L in 97.5% of Caucasian and Somali women was 8 and 18 µg/day, respectively. Ethnic differences were also evident at 40 and 50 nmol/L serum 25(OH)D thresholds. Conclusion: The present study adds further evidence that ethnic differences in the dietary requirement for vitamin D do exist and that dose–response vitamin D intervention studies are required in at-risk target populations specified by ethnicity.

KW - Dietary reference values

KW - Ethnic-related differences

KW - RCT

KW - Vitamin D requirements

U2 - 10.1007/s00394-018-1775-1

DO - 10.1007/s00394-018-1775-1

M3 - Journal article

C2 - 30022296

AN - SCOPUS:85050240670

SN - 1436-6207

VL - 58

SP - 2281

EP - 2291

JO - European Journal of Nutrition

JF - European Journal of Nutrition

IS - 6

ER -