Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark

Carsten Lindberg Fagö-Olsen; Bent Ottesen; Henrik Kehlet; Sofie Leisby Antonsen; Ib Jarle Christensen; Algirdas Markauskas; Berit Jul Mosgaard; Christian Ottosen; Charlotte Hasselholt Sogaard; Claus Hoegdall

doi:10.1097/igc.0000000000000200

Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark

Carsten Lindberg Fagö-Olsen, Bent Ottesen, Henrik Kehlet, Sofie Leisby Antonsen, Ib Jarle Christensen, Algirdas Markauskas, Berit Jul Mosgaard, Christian Ottosen, Charlotte Hasselholt Sogaard, Claus Hoegdall

6 Citations (Scopus)

Abstract

BACKGROUND: Triage of patients with ovarian cancer to primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) is challenging. In Denmark, the use of NACT has increased, but substantial differences in the use of NACT or PDS exist among centers. We aimed to characterize the differences between intended and actual first-line treatments in addition to the differences in the triage process among the centers and to evaluate the different diagnostic modalities and the clinical aspects' influence in the triage process.

MATERIALS AND METHODS: From 4 centers, forms containing data about the diagnostic process and intended treatment were prospectively collected and merged with data from the Danish Gynecological Cancer Database and medical records.

RESULTS: Of the 671 completed forms, 540 patients had stage IIIC or IV epithelial ovarian cancer. Of the 238 (44%) referred to PDS, 91% received PDS and 4% never had debulking surgery. Of the 288 patients (53%) referred to NACT, 44% were never debulked. Fourteen patients (3%) were referred to palliative treatment. The use of different imaging modalities, diagnostic laparoscopy, and laparotomy varied significantly among the centers. Diagnostic surgical procedures were considered to be most influential in the triage process. Regardless of the intended first-line treatment or center, the tumor size and dissemination was the most influential clinical aspect.

CONCLUSIONS: In Denmark, substantial differences exist between intended and actual first-line treatments as well as in the diagnostic process and use of NACT, calling for further discussion on diagnostic strategy and therapeutically approach for patients with advanced ovarian cancer.

Original language	English
Journal	International Journal of Gynecological Cancer
Volume	24
Issue number	7
Pages (from-to)	1195–1205
Number of pages	11
ISSN	1048-891X
DOIs	https://doi.org/10.1097/igc.0000000000000200
Publication status	Published - Sept 2014

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Fagö-Olsen, C. L., Ottesen, B., Kehlet, H., Antonsen, S. L., Christensen, I. J., Markauskas, A., Mosgaard, B. J., Ottosen, C., Sogaard, C. H., & Hoegdall, C. (2014). Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark. International Journal of Gynecological Cancer, 24(7), 1195–1205. https://doi.org/10.1097/igc.0000000000000200

Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark. / Fagö-Olsen, Carsten Lindberg; Ottesen, Bent; Kehlet, Henrik et al.

In: International Journal of Gynecological Cancer, Vol. 24, No. 7, 09.2014, p. 1195–1205.

Research output: Contribution to journal › Journal article › Research › peer-review

Fagö-Olsen, CL, Ottesen, B, Kehlet, H, Antonsen, SL, Christensen, IJ, Markauskas, A, Mosgaard, BJ, Ottosen, C, Sogaard, CH & Hoegdall, C 2014, 'Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark', International Journal of Gynecological Cancer, vol. 24, no. 7, pp. 1195–1205. https://doi.org/10.1097/igc.0000000000000200

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title = "Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark",

abstract = "BACKGROUND: Triage of patients with ovarian cancer to primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) is challenging. In Denmark, the use of NACT has increased, but substantial differences in the use of NACT or PDS exist among centers. We aimed to characterize the differences between intended and actual first-line treatments in addition to the differences in the triage process among the centers and to evaluate the different diagnostic modalities and the clinical aspects' influence in the triage process.MATERIALS AND METHODS: From 4 centers, forms containing data about the diagnostic process and intended treatment were prospectively collected and merged with data from the Danish Gynecological Cancer Database and medical records.RESULTS: Of the 671 completed forms, 540 patients had stage IIIC or IV epithelial ovarian cancer. Of the 238 (44%) referred to PDS, 91% received PDS and 4% never had debulking surgery. Of the 288 patients (53%) referred to NACT, 44% were never debulked. Fourteen patients (3%) were referred to palliative treatment. The use of different imaging modalities, diagnostic laparoscopy, and laparotomy varied significantly among the centers. Diagnostic surgical procedures were considered to be most influential in the triage process. Regardless of the intended first-line treatment or center, the tumor size and dissemination was the most influential clinical aspect.CONCLUSIONS: In Denmark, substantial differences exist between intended and actual first-line treatments as well as in the diagnostic process and use of NACT, calling for further discussion on diagnostic strategy and therapeutically approach for patients with advanced ovarian cancer.",

author = "Fag{\"o}-Olsen, {Carsten Lindberg} and Bent Ottesen and Henrik Kehlet and Antonsen, {Sofie Leisby} and Christensen, {Ib Jarle} and Algirdas Markauskas and Mosgaard, {Berit Jul} and Christian Ottosen and Sogaard, {Charlotte Hasselholt} and Claus Hoegdall",

year = "2014",

month = sep,

doi = "10.1097/igc.0000000000000200",

language = "English",

volume = "24",

pages = "1195–1205",

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T1 - Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark

AU - Fagö-Olsen, Carsten Lindberg

AU - Ottesen, Bent

AU - Kehlet, Henrik

AU - Antonsen, Sofie Leisby

AU - Christensen, Ib Jarle

AU - Markauskas, Algirdas

AU - Mosgaard, Berit Jul

AU - Ottosen, Christian

AU - Sogaard, Charlotte Hasselholt

AU - Hoegdall, Claus

PY - 2014/9

Y1 - 2014/9

N2 - BACKGROUND: Triage of patients with ovarian cancer to primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) is challenging. In Denmark, the use of NACT has increased, but substantial differences in the use of NACT or PDS exist among centers. We aimed to characterize the differences between intended and actual first-line treatments in addition to the differences in the triage process among the centers and to evaluate the different diagnostic modalities and the clinical aspects' influence in the triage process.MATERIALS AND METHODS: From 4 centers, forms containing data about the diagnostic process and intended treatment were prospectively collected and merged with data from the Danish Gynecological Cancer Database and medical records.RESULTS: Of the 671 completed forms, 540 patients had stage IIIC or IV epithelial ovarian cancer. Of the 238 (44%) referred to PDS, 91% received PDS and 4% never had debulking surgery. Of the 288 patients (53%) referred to NACT, 44% were never debulked. Fourteen patients (3%) were referred to palliative treatment. The use of different imaging modalities, diagnostic laparoscopy, and laparotomy varied significantly among the centers. Diagnostic surgical procedures were considered to be most influential in the triage process. Regardless of the intended first-line treatment or center, the tumor size and dissemination was the most influential clinical aspect.CONCLUSIONS: In Denmark, substantial differences exist between intended and actual first-line treatments as well as in the diagnostic process and use of NACT, calling for further discussion on diagnostic strategy and therapeutically approach for patients with advanced ovarian cancer.

AB - BACKGROUND: Triage of patients with ovarian cancer to primary debulking surgery (PDS) or neoadjuvant chemotherapy (NACT) is challenging. In Denmark, the use of NACT has increased, but substantial differences in the use of NACT or PDS exist among centers. We aimed to characterize the differences between intended and actual first-line treatments in addition to the differences in the triage process among the centers and to evaluate the different diagnostic modalities and the clinical aspects' influence in the triage process.MATERIALS AND METHODS: From 4 centers, forms containing data about the diagnostic process and intended treatment were prospectively collected and merged with data from the Danish Gynecological Cancer Database and medical records.RESULTS: Of the 671 completed forms, 540 patients had stage IIIC or IV epithelial ovarian cancer. Of the 238 (44%) referred to PDS, 91% received PDS and 4% never had debulking surgery. Of the 288 patients (53%) referred to NACT, 44% were never debulked. Fourteen patients (3%) were referred to palliative treatment. The use of different imaging modalities, diagnostic laparoscopy, and laparotomy varied significantly among the centers. Diagnostic surgical procedures were considered to be most influential in the triage process. Regardless of the intended first-line treatment or center, the tumor size and dissemination was the most influential clinical aspect.CONCLUSIONS: In Denmark, substantial differences exist between intended and actual first-line treatments as well as in the diagnostic process and use of NACT, calling for further discussion on diagnostic strategy and therapeutically approach for patients with advanced ovarian cancer.

U2 - 10.1097/igc.0000000000000200

DO - 10.1097/igc.0000000000000200

M3 - Journal article

C2 - 25101855

SN - 1048-891X

VL - 24

SP - 1195

EP - 1205

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

IS - 7

ER -

Differences in Regional Diagnostic Strategies and in Intended Versus Actual First-Line Treatment of Patients With Advanced Ovarian Cancer in Denmark

Abstract

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