Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system

Lise G Bie-Olsen; Ulrik Pedersen-Bjergaard; Troels W Kjaer; Markus Georg Lonsdale; Ian Law; Birger Thorsteinsson

doi:10.1177/1470320310364182

Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system

Lise G Bie-Olsen, Ulrik Pedersen-Bjergaard, Troels W Kjaer, Markus Georg Lonsdale, Ian Law, Birger Thorsteinsson

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Abstract

INTRODUCTION: High renin-angiotensin system (RAS) activity has been associated with a high risk of severe hypoglycaemia in patients with type 1 diabetes and with cognitive deterioration during experimental hypoglycaemia in healthy subjects. The aim of this study was to describe possible differences in cerebral activity during hypoglycaemia and cognitive testing in two groups of healthy men with different basal RAS activity. METHODS: Ten healthy men with high RAS activity and 10 with low activity underwent six oxygen-15-labelled water positron emission tomography scans: twice during normoglycaemia, twice during insulin-induced hypoglycaemia and twice during post-hypoglycaemia. During the scans, the subjects performed a computer-based reaction time test. RESULTS: Occipital areas were consistently more activated in the low RAS group than in the high RAS group throughout all three conditions. During normoglycaemia, the frontal region was more activated in the low RAS group than in the high RAS group. During hypoglycaemia, the high RAS group was more activated in the pituitary gland than the low RAS group. CONCLUSION: Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response.

Original language	English
Journal	Journal of the Renin-Angiotensin-Aldosterone System
Volume	11
Issue number	3
Pages (from-to)	173-9
Number of pages	7
ISSN	1470-3203
DOIs	https://doi.org/10.1177/1470320310364182
Publication status	Published - 1 Sept 2010

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Bie-Olsen, L. G., Pedersen-Bjergaard, U., Kjaer, T. W., Lonsdale, M. G., Law, I., & Thorsteinsson, B. (2010). Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system. Journal of the Renin-Angiotensin-Aldosterone System, 11(3), 173-9. https://doi.org/10.1177/1470320310364182

Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system. / Bie-Olsen, Lise G; Pedersen-Bjergaard, Ulrik; Kjaer, Troels W et al.
In: Journal of the Renin-Angiotensin-Aldosterone System, Vol. 11, No. 3, 01.09.2010, p. 173-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Bie-Olsen, LG, Pedersen-Bjergaard, U, Kjaer, TW, Lonsdale, MG, Law, I & Thorsteinsson, B 2010, 'Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system', Journal of the Renin-Angiotensin-Aldosterone System, vol. 11, no. 3, pp. 173-9. https://doi.org/10.1177/1470320310364182

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title = "Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system",

abstract = "INTRODUCTION: High renin-angiotensin system (RAS) activity has been associated with a high risk of severe hypoglycaemia in patients with type 1 diabetes and with cognitive deterioration during experimental hypoglycaemia in healthy subjects. The aim of this study was to describe possible differences in cerebral activity during hypoglycaemia and cognitive testing in two groups of healthy men with different basal RAS activity. METHODS: Ten healthy men with high RAS activity and 10 with low activity underwent six oxygen-15-labelled water positron emission tomography scans: twice during normoglycaemia, twice during insulin-induced hypoglycaemia and twice during post-hypoglycaemia. During the scans, the subjects performed a computer-based reaction time test. RESULTS: Occipital areas were consistently more activated in the low RAS group than in the high RAS group throughout all three conditions. During normoglycaemia, the frontal region was more activated in the low RAS group than in the high RAS group. During hypoglycaemia, the high RAS group was more activated in the pituitary gland than the low RAS group. CONCLUSION: Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response.",

author = "Bie-Olsen, {Lise G} and Ulrik Pedersen-Bjergaard and Kjaer, {Troels W} and Lonsdale, {Markus Georg} and Ian Law and Birger Thorsteinsson",

year = "2010",

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doi = "10.1177/1470320310364182",

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T1 - Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system

AU - Bie-Olsen, Lise G

AU - Pedersen-Bjergaard, Ulrik

AU - Kjaer, Troels W

AU - Lonsdale, Markus Georg

AU - Law, Ian

AU - Thorsteinsson, Birger

PY - 2010/9/1

Y1 - 2010/9/1

N2 - INTRODUCTION: High renin-angiotensin system (RAS) activity has been associated with a high risk of severe hypoglycaemia in patients with type 1 diabetes and with cognitive deterioration during experimental hypoglycaemia in healthy subjects. The aim of this study was to describe possible differences in cerebral activity during hypoglycaemia and cognitive testing in two groups of healthy men with different basal RAS activity. METHODS: Ten healthy men with high RAS activity and 10 with low activity underwent six oxygen-15-labelled water positron emission tomography scans: twice during normoglycaemia, twice during insulin-induced hypoglycaemia and twice during post-hypoglycaemia. During the scans, the subjects performed a computer-based reaction time test. RESULTS: Occipital areas were consistently more activated in the low RAS group than in the high RAS group throughout all three conditions. During normoglycaemia, the frontal region was more activated in the low RAS group than in the high RAS group. During hypoglycaemia, the high RAS group was more activated in the pituitary gland than the low RAS group. CONCLUSION: Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response.

AB - INTRODUCTION: High renin-angiotensin system (RAS) activity has been associated with a high risk of severe hypoglycaemia in patients with type 1 diabetes and with cognitive deterioration during experimental hypoglycaemia in healthy subjects. The aim of this study was to describe possible differences in cerebral activity during hypoglycaemia and cognitive testing in two groups of healthy men with different basal RAS activity. METHODS: Ten healthy men with high RAS activity and 10 with low activity underwent six oxygen-15-labelled water positron emission tomography scans: twice during normoglycaemia, twice during insulin-induced hypoglycaemia and twice during post-hypoglycaemia. During the scans, the subjects performed a computer-based reaction time test. RESULTS: Occipital areas were consistently more activated in the low RAS group than in the high RAS group throughout all three conditions. During normoglycaemia, the frontal region was more activated in the low RAS group than in the high RAS group. During hypoglycaemia, the high RAS group was more activated in the pituitary gland than the low RAS group. CONCLUSION: Basal RAS activity influenced cerebral activity. Low RAS was associated with more pronounced cortical activation in all glycaemic conditions. High RAS was associated with pituitary activation during hypoglycaemia and post-hypoglycaemia, and this was associated with a greater growth hormone response.

U2 - 10.1177/1470320310364182

DO - 10.1177/1470320310364182

M3 - Journal article

SN - 1470-3203

VL - 11

SP - 173

EP - 179

JO - Journal of the Renin-Angiotensin-Aldosterone System

JF - Journal of the Renin-Angiotensin-Aldosterone System

IS - 3

ER -

Differences in cortical and pituitary activity in response to hypoglycaemia and cognitive testing in healthy men with different basal activity of the renin-angiotensin system

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