Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study

Cecilie Kyrø; Mette Bredal Kristensen; Marianne Uhre Jakobsen; Jytte Halkjær; Rikard Landberg; H B as Bueno-de-Mesquita; J Christensen; Isabelle Romieu; Anne Tjønneland; A Olsen

doi:10.1038/ejcn.2016.233

Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study

Cecilie Kyrø, Mette Bredal Kristensen, Marianne Uhre Jakobsen, Jytte Halkjær, Rikard Landberg, H B as Bueno-de-Mesquita, J Christensen, Isabelle Romieu, Anne Tjønneland, A Olsen

Nutrition and Health

2 Citations (Scopus)

Abstract

Background/Objectives:Whole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight.Subjects/Methods:Cohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression.Results:For women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: -0.69 cm, 95% CI:-1.26 cm;-0.13 cm), but no association was found for men.Conclusions:Overall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	71
Issue number	8
Pages (from-to)	944-952
Number of pages	9
ISSN	0954-3007
DOIs	https://doi.org/10.1038/ejcn.2016.233
Publication status	Published - 1 Aug 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ejcn.2016.233

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Kyrø, C., Kristensen, M. B., Jakobsen, M. U., Halkjær, J., Landberg, R., Bueno-de-Mesquita, H. B. A., Christensen, J., Romieu, I., Tjønneland, A., & Olsen, A. (2017). Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study. European Journal of Clinical Nutrition, 71(8), 944-952. https://doi.org/10.1038/ejcn.2016.233

Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry : the Danish diet, cancer and health cohort study. / Kyrø, Cecilie; Kristensen, Mette Bredal; Jakobsen, Marianne Uhre et al.

In: European Journal of Clinical Nutrition, Vol. 71, No. 8, 01.08.2017, p. 944-952.

Research output: Contribution to journal › Journal article › Research › peer-review

Kyrø, C, Kristensen, MB, Jakobsen, MU, Halkjær, J, Landberg, R, Bueno-de-Mesquita, HBA, Christensen, J, Romieu, I, Tjønneland, A & Olsen, A 2017, 'Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study', European Journal of Clinical Nutrition, vol. 71, no. 8, pp. 944-952. https://doi.org/10.1038/ejcn.2016.233

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abstract = "Background/Objectives:Whole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight.Subjects/Methods:Cohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression.Results:For women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: -0.69 cm, 95% CI:-1.26 cm;-0.13 cm), but no association was found for men.Conclusions:Overall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.",

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T1 - Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry

T2 - the Danish diet, cancer and health cohort study

AU - Kyrø, Cecilie

AU - Kristensen, Mette Bredal

AU - Jakobsen, Marianne Uhre

AU - Halkjær, Jytte

AU - Landberg, Rikard

AU - Bueno-de-Mesquita, H B as

AU - Christensen, J

AU - Romieu, Isabelle

AU - Tjønneland, Anne

AU - Olsen, A

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N2 - Background/Objectives:Whole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight.Subjects/Methods:Cohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression.Results:For women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: -0.69 cm, 95% CI:-1.26 cm;-0.13 cm), but no association was found for men.Conclusions:Overall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.

AB - Background/Objectives:Whole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight.Subjects/Methods:Cohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression.Results:For women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: -0.69 cm, 95% CI:-1.26 cm;-0.13 cm), but no association was found for men.Conclusions:Overall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.

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DO - 10.1038/ejcn.2016.233

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C2 - 28176776

SN - 0954-3007

VL - 71

SP - 944

EP - 952

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 8

ER -

Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort study

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Keywords

UN SDGs

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