Dietary factors impact on the association between CTSS variants and obesity related traits

Henri Hooton; Lars Henrik Ängquist; Claus Holst; Jorg Hager; Francis Rousseau; Rikke D Hansen; Anne Tjønneland; Nina Roswall; Daphne L van der A; Kim Overvad; Marianne Uhre Jakobsen; Heiner Boeing; Karina Meidtner; Domenico Palli; Giovanna Masala; Nabila Bouatia-Naji; Wim H M Saris; Edith J M Feskens; Nicolas J Wareham; Karani S Vimaleswaran; Dominique Langin; Ruth J F Loos; Thorkild I A Sørensen; Karine Clément

doi:10.1371/journal.pone.0040394

Dietary factors impact on the association between CTSS variants and obesity related traits

Henri Hooton, Lars Henrik Ängquist, Claus Holst, Jorg Hager, Francis Rousseau, Rikke D Hansen, Anne Tjønneland, Nina Roswall, Daphne L van der A, Kim Overvad, Marianne Uhre Jakobsen, Heiner Boeing, Karina Meidtner, Domenico Palli, Giovanna Masala, Nabila Bouatia-Naji, Wim H M Saris, Edith J M Feskens, Nicolas J Wareham, Karani S VimaleswaranDominique Langin, Ruth J F Loos, Thorkild I A Sørensen, Karine Clément

9 Citations (Scopus)

Abstract

Background/Aims:Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology-this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors-increased by high protein, glycemic index and energy diets.Methods:Four tag SNPs (rs7511673, rs11576175, rs10888390 and rs1136774) were selected to capture all common variation in the CTSS region. Association between these four SNPs and several adiposity measurements (BMI, waist circumference, waist for given BMI and being a weight gainer-experiencing the greatest degree of unexplained annual weight gain during follow-up or not) given, where applicable, both as baseline values and gain during the study period (6-8 years) were tested in 11,091 European individuals (linear or logistic regression models). We also examined the interaction between the CTSS variants and dietary factors-energy density, protein content (in grams or in % of total energy intake) and glycemic index-on these four adiposity phenotypes.Results:We found several associations between CTSS polymorphisms and anthropometric traits including baseline BMI (rs11576175 (SNP N°2), p = 0.02, β = -0.2446), and waist change over time (rs7511673 (SNP N°1), p = 0.01, β = -0.0433 and rs10888390 (SNP N°3), p = 0.04, β = -0.0342). In interaction with the percentage of proteins contained in the diet, rs11576175 (SNP N°2) was also associated with the risk of being a weight gainer (p_interaction = 0.01, OR = 1.0526)-the risk of being a weight gainer increased with the percentage of proteins contained in the diet.Conclusion:CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.

Original language	English
Journal	P L o S One
Volume	7
Issue number	7
Pages (from-to)	e40394
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0040394
Publication status	Published - 23 Jul 2012

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Hooton, H., Ängquist, L. H., Holst, C., Hager, J., Rousseau, F., Hansen, R. D., Tjønneland, A., Roswall, N., van der A, D. L., Overvad, K., Jakobsen, M. U., Boeing, H., Meidtner, K., Palli, D., Masala, G., Bouatia-Naji, N., Saris, W. H. M., Feskens, E. J. M., Wareham, N. J., ... Clément, K. (2012). Dietary factors impact on the association between CTSS variants and obesity related traits. P L o S One, 7(7), e40394. https://doi.org/10.1371/journal.pone.0040394

Hooton, H, Ängquist, LH, Holst, C, Hager, J, Rousseau, F, Hansen, RD, Tjønneland, A, Roswall, N, van der A, DL, Overvad, K, Jakobsen, MU, Boeing, H, Meidtner, K, Palli, D, Masala, G, Bouatia-Naji, N, Saris, WHM, Feskens, EJM, Wareham, NJ, Vimaleswaran, KS, Langin, D, Loos, RJF, Sørensen, TIA & Clément, K 2012, 'Dietary factors impact on the association between CTSS variants and obesity related traits', P L o S One, vol. 7, no. 7, pp. e40394. https://doi.org/10.1371/journal.pone.0040394

@article{e2afebf0915e41b3884ba3fe4673afba,

title = "Dietary factors impact on the association between CTSS variants and obesity related traits",

abstract = "Background/Aims:Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology-this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors-increased by high protein, glycemic index and energy diets.Methods:Four tag SNPs (rs7511673, rs11576175, rs10888390 and rs1136774) were selected to capture all common variation in the CTSS region. Association between these four SNPs and several adiposity measurements (BMI, waist circumference, waist for given BMI and being a weight gainer-experiencing the greatest degree of unexplained annual weight gain during follow-up or not) given, where applicable, both as baseline values and gain during the study period (6-8 years) were tested in 11,091 European individuals (linear or logistic regression models). We also examined the interaction between the CTSS variants and dietary factors-energy density, protein content (in grams or in % of total energy intake) and glycemic index-on these four adiposity phenotypes.Results:We found several associations between CTSS polymorphisms and anthropometric traits including baseline BMI (rs11576175 (SNP N°2), p = 0.02, β = -0.2446), and waist change over time (rs7511673 (SNP N°1), p = 0.01, β = -0.0433 and rs10888390 (SNP N°3), p = 0.04, β = -0.0342). In interaction with the percentage of proteins contained in the diet, rs11576175 (SNP N°2) was also associated with the risk of being a weight gainer (pinteraction = 0.01, OR = 1.0526)-the risk of being a weight gainer increased with the percentage of proteins contained in the diet.Conclusion:CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.",

author = "Henri Hooton and {\"A}ngquist, {Lars Henrik} and Claus Holst and Jorg Hager and Francis Rousseau and Hansen, {Rikke D} and Anne Tj{\o}nneland and Nina Roswall and {van der A}, {Daphne L} and Kim Overvad and Jakobsen, {Marianne Uhre} and Heiner Boeing and Karina Meidtner and Domenico Palli and Giovanna Masala and Nabila Bouatia-Naji and Saris, {Wim H M} and Feskens, {Edith J M} and Wareham, {Nicolas J} and Vimaleswaran, {Karani S} and Dominique Langin and Loos, {Ruth J F} and S{\o}rensen, {Thorkild I A} and Karine Cl{\'e}ment",

year = "2012",

month = jul,

day = "23",

doi = "10.1371/journal.pone.0040394",

language = "English",

volume = "7",

pages = "e40394",

journal = "PLoS Computational Biology",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "7",

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TY - JOUR

T1 - Dietary factors impact on the association between CTSS variants and obesity related traits

AU - Hooton, Henri

AU - Ängquist, Lars Henrik

AU - Holst, Claus

AU - Hager, Jorg

AU - Rousseau, Francis

AU - Hansen, Rikke D

AU - Tjønneland, Anne

AU - Roswall, Nina

AU - van der A, Daphne L

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Boeing, Heiner

AU - Meidtner, Karina

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Bouatia-Naji, Nabila

AU - Saris, Wim H M

AU - Feskens, Edith J M

AU - Wareham, Nicolas J

AU - Vimaleswaran, Karani S

AU - Langin, Dominique

AU - Loos, Ruth J F

AU - Sørensen, Thorkild I A

AU - Clément, Karine

PY - 2012/7/23

Y1 - 2012/7/23

N2 - Background/Aims:Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology-this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors-increased by high protein, glycemic index and energy diets.Methods:Four tag SNPs (rs7511673, rs11576175, rs10888390 and rs1136774) were selected to capture all common variation in the CTSS region. Association between these four SNPs and several adiposity measurements (BMI, waist circumference, waist for given BMI and being a weight gainer-experiencing the greatest degree of unexplained annual weight gain during follow-up or not) given, where applicable, both as baseline values and gain during the study period (6-8 years) were tested in 11,091 European individuals (linear or logistic regression models). We also examined the interaction between the CTSS variants and dietary factors-energy density, protein content (in grams or in % of total energy intake) and glycemic index-on these four adiposity phenotypes.Results:We found several associations between CTSS polymorphisms and anthropometric traits including baseline BMI (rs11576175 (SNP N°2), p = 0.02, β = -0.2446), and waist change over time (rs7511673 (SNP N°1), p = 0.01, β = -0.0433 and rs10888390 (SNP N°3), p = 0.04, β = -0.0342). In interaction with the percentage of proteins contained in the diet, rs11576175 (SNP N°2) was also associated with the risk of being a weight gainer (pinteraction = 0.01, OR = 1.0526)-the risk of being a weight gainer increased with the percentage of proteins contained in the diet.Conclusion:CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.

AB - Background/Aims:Cathepsin S, a protein coded by the CTSS gene, is implicated in adipose tissue biology-this protein enhances adipose tissue development. Our hypothesis is that common variants in CTSS play a role in body weight regulation and in the development of obesity and that these effects are influenced by dietary factors-increased by high protein, glycemic index and energy diets.Methods:Four tag SNPs (rs7511673, rs11576175, rs10888390 and rs1136774) were selected to capture all common variation in the CTSS region. Association between these four SNPs and several adiposity measurements (BMI, waist circumference, waist for given BMI and being a weight gainer-experiencing the greatest degree of unexplained annual weight gain during follow-up or not) given, where applicable, both as baseline values and gain during the study period (6-8 years) were tested in 11,091 European individuals (linear or logistic regression models). We also examined the interaction between the CTSS variants and dietary factors-energy density, protein content (in grams or in % of total energy intake) and glycemic index-on these four adiposity phenotypes.Results:We found several associations between CTSS polymorphisms and anthropometric traits including baseline BMI (rs11576175 (SNP N°2), p = 0.02, β = -0.2446), and waist change over time (rs7511673 (SNP N°1), p = 0.01, β = -0.0433 and rs10888390 (SNP N°3), p = 0.04, β = -0.0342). In interaction with the percentage of proteins contained in the diet, rs11576175 (SNP N°2) was also associated with the risk of being a weight gainer (pinteraction = 0.01, OR = 1.0526)-the risk of being a weight gainer increased with the percentage of proteins contained in the diet.Conclusion:CTSS variants seem to be nominally associated to obesity related traits and this association may be modified by dietary protein intake.

U2 - 10.1371/journal.pone.0040394

DO - 10.1371/journal.pone.0040394

M3 - Journal article

SN - 1932-6203

VL - 7

SP - e40394

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 7

ER -

Dietary factors impact on the association between CTSS variants and obesity related traits

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