Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy

Christian Jons; Rikke Moerch Joergensen; Christian Hassager; Uffe Jakob Ortved Gang; Ulrik Dixen; Arne Johannesen; Niels Thue Olsen; Thomas F Hansen; Marc Messier; Heikki V Huikuri; Poul Erik Bloch Thomsen; Uffe Jacob Ortved Gang; Niels Thue Olsen

doi:10.1093/ejechocard/jeq024

Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy

Christian Jons, Rikke Moerch Joergensen, Christian Hassager, Uffe Jakob Ortved Gang, Ulrik Dixen, Arne Johannesen, Niels Thue Olsen, Thomas F Hansen, Marc Messier, Heikki V Huikuri, Poul Erik Bloch Thomsen, Uffe Jacob Ortved Gang, Niels Thue Olsen

45 Citations (Scopus)

Abstract

Aims The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence of new-onset atrial fibrillation (AF) and cardiac events in patients with acute myocardial infarction (AMI) and left ventricular (LV) systolic dysfunction. Methods and results The study was performed as a substudy on the CARISMA study population. The CARISMA study enrolled 312 patients with an AMI and LV ejection fraction ≤40. Patients were implanted with an implantable loop recorder and followed for 2 years. Sixty-two patients had a full echocardiographic assessment of the diastolic function using tissue Doppler analysis performed 6 weeks after the AMI. The endpoints were: (i) new-onset AF and (ii) major cardiovascular events (MACE) defined as re-infarction, stroke, or cardiovascular death. Twenty-four patients had diastolic dysfunction, whereas 38 patients had normal diastolic function. Diastolic dysfunction was associated with an increased risk of new-onset AF [HR = 5.30 (1.68-16.75), P = 0.005] and MACE [HR = 4.70 (1.25-17.75), P = 0.022] after adjustment for age, sex, NYHA class, and hypertension. Conclusion Diastolic dysfunction in post-MI patients with LV systolic dysfunction predisposes to new-onset AF and MACE.

Original language	English
Journal	European Journal of Echocardiography
Volume	11
Issue number	7
Pages (from-to)	602-7
Number of pages	6
ISSN	1525-2167
DOIs	https://doi.org/10.1093/ejechocard/jeq024
Publication status	Published - 1 Aug 2010

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Jons, C., Joergensen, R. M., Hassager, C., Gang, U. J. O., Dixen, U., Johannesen, A., Olsen, N. T., Hansen, T. F., Messier, M., Huikuri, H. V., Thomsen, P. E. B., Gang, U. J. O., & Olsen, N. T. (2010). Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy. European Journal of Echocardiography, 11(7), 602-7. https://doi.org/10.1093/ejechocard/jeq024

Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy. / Jons, Christian; Joergensen, Rikke Moerch; Hassager, Christian et al.
In: European Journal of Echocardiography, Vol. 11, No. 7, 01.08.2010, p. 602-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Jons, C, Joergensen, RM, Hassager, C, Gang, UJO, Dixen, U, Johannesen, A, Olsen, NT, Hansen, TF, Messier, M, Huikuri, HV, Thomsen, PEB, Gang, UJO & Olsen, NT 2010, 'Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy', European Journal of Echocardiography, vol. 11, no. 7, pp. 602-7. https://doi.org/10.1093/ejechocard/jeq024

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title = "Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy",

abstract = "Aims The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence of new-onset atrial fibrillation (AF) and cardiac events in patients with acute myocardial infarction (AMI) and left ventricular (LV) systolic dysfunction. Methods and results The study was performed as a substudy on the CARISMA study population. The CARISMA study enrolled 312 patients with an AMI and LV ejection fraction ≤40. Patients were implanted with an implantable loop recorder and followed for 2 years. Sixty-two patients had a full echocardiographic assessment of the diastolic function using tissue Doppler analysis performed 6 weeks after the AMI. The endpoints were: (i) new-onset AF and (ii) major cardiovascular events (MACE) defined as re-infarction, stroke, or cardiovascular death. Twenty-four patients had diastolic dysfunction, whereas 38 patients had normal diastolic function. Diastolic dysfunction was associated with an increased risk of new-onset AF [HR = 5.30 (1.68-16.75), P = 0.005] and MACE [HR = 4.70 (1.25-17.75), P = 0.022] after adjustment for age, sex, NYHA class, and hypertension. Conclusion Diastolic dysfunction in post-MI patients with LV systolic dysfunction predisposes to new-onset AF and MACE.",

author = "Christian Jons and Joergensen, {Rikke Moerch} and Christian Hassager and Gang, {Uffe Jakob Ortved} and Ulrik Dixen and Arne Johannesen and Olsen, {Niels Thue} and Hansen, {Thomas F} and Marc Messier and Huikuri, {Heikki V} and Thomsen, {Poul Erik Bloch} and Gang, {Uffe Jacob Ortved} and Olsen, {Niels Thue}",

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doi = "10.1093/ejechocard/jeq024",

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T1 - Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy

AU - Jons, Christian

AU - Joergensen, Rikke Moerch

AU - Hassager, Christian

AU - Gang, Uffe Jakob Ortved

AU - Dixen, Ulrik

AU - Johannesen, Arne

AU - Olsen, Niels Thue

AU - Hansen, Thomas F

AU - Messier, Marc

AU - Huikuri, Heikki V

AU - Thomsen, Poul Erik Bloch

AU - Gang, Uffe Jacob Ortved

AU - Olsen, Niels Thue

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Aims The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence of new-onset atrial fibrillation (AF) and cardiac events in patients with acute myocardial infarction (AMI) and left ventricular (LV) systolic dysfunction. Methods and results The study was performed as a substudy on the CARISMA study population. The CARISMA study enrolled 312 patients with an AMI and LV ejection fraction ≤40. Patients were implanted with an implantable loop recorder and followed for 2 years. Sixty-two patients had a full echocardiographic assessment of the diastolic function using tissue Doppler analysis performed 6 weeks after the AMI. The endpoints were: (i) new-onset AF and (ii) major cardiovascular events (MACE) defined as re-infarction, stroke, or cardiovascular death. Twenty-four patients had diastolic dysfunction, whereas 38 patients had normal diastolic function. Diastolic dysfunction was associated with an increased risk of new-onset AF [HR = 5.30 (1.68-16.75), P = 0.005] and MACE [HR = 4.70 (1.25-17.75), P = 0.022] after adjustment for age, sex, NYHA class, and hypertension. Conclusion Diastolic dysfunction in post-MI patients with LV systolic dysfunction predisposes to new-onset AF and MACE.

AB - Aims The aim of this study was to investigate the association between diastolic dysfunction and long-term occurrence of new-onset atrial fibrillation (AF) and cardiac events in patients with acute myocardial infarction (AMI) and left ventricular (LV) systolic dysfunction. Methods and results The study was performed as a substudy on the CARISMA study population. The CARISMA study enrolled 312 patients with an AMI and LV ejection fraction ≤40. Patients were implanted with an implantable loop recorder and followed for 2 years. Sixty-two patients had a full echocardiographic assessment of the diastolic function using tissue Doppler analysis performed 6 weeks after the AMI. The endpoints were: (i) new-onset AF and (ii) major cardiovascular events (MACE) defined as re-infarction, stroke, or cardiovascular death. Twenty-four patients had diastolic dysfunction, whereas 38 patients had normal diastolic function. Diastolic dysfunction was associated with an increased risk of new-onset AF [HR = 5.30 (1.68-16.75), P = 0.005] and MACE [HR = 4.70 (1.25-17.75), P = 0.022] after adjustment for age, sex, NYHA class, and hypertension. Conclusion Diastolic dysfunction in post-MI patients with LV systolic dysfunction predisposes to new-onset AF and MACE.

U2 - 10.1093/ejechocard/jeq024

DO - 10.1093/ejechocard/jeq024

M3 - Journal article

SN - 1525-2167

VL - 11

SP - 602

EP - 607

JO - European Journal of Echocardiography

JF - European Journal of Echocardiography

IS - 7

ER -

Diastolic dysfunction predicts new-onset atrial fibrillation and cardiovascular events in patients with acute myocardial infarction and depressed left ventricular systolic function: a CARISMA substudy

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