Diamond nanoparticles modity curcumin activity: in vitro studies on cancer and normal cells and in ovo studies on chicken embryo model

Barbara Strojny; Marta Grodzik; Ewa Sawosz; Anna Winnicka; Natalia Kurantowicz; Slawomir Jaworski; Marta Kutwin; Kaja Urbanska; Anna Hotowy; Mateusz Wierzbicki; André Chwalibog

doi:10.1371/journal.pone.0164637

Diamond nanoparticles modity curcumin activity: in vitro studies on cancer and normal cells and in ovo studies on chicken embryo model

Barbara Strojny, Marta Grodzik, Ewa Sawosz, Anna Winnicka, Natalia Kurantowicz, Slawomir Jaworski, Marta Kutwin, Kaja Urbanska, Anna Hotowy, Mateusz Wierzbicki, André Chwalibog

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Abstract

Curcumin has been studied broadly for its wide range of biological activities, including anticancer properties. The major problem with curcumin is its poor bioavailability, which can be improved by the addition of carriers, such as diamond nanoparticles (DN). They are carbon allotropes, and are therefore biocompatible and easily taken up by cells. DN are non-toxic and have antiangiogenic properties with potential applications in cancer therapy. Their large surface makes them promising compounds in a drug delivery system for bioactive agents, as DN create bio-complexes in a fast and simple process of self-organisation. We investigated the cytotoxicity of such bio-complexes against liver cancer cells and normal fibroblasts, revealing that conjugation of curcumin with DN significantly improves its activity. The experiment performed in a chicken embryo model demonstrated that neither curcumin nor DN nor bio-complexes affect embryo development, even though DN can form deposits in tissues. Preliminary results confirmed the applicability of DN as an efficient carrier of curcumin, which improves its performance against cancer cells in vitro, yet is not toxic to an organism, which makes the bio-complex a promising anticancer agent.

Original language	English
Article number	e0164637
Journal	P L o S One
Volume	11
Issue number	10
Number of pages	18
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0164637
Publication status	Published - Oct 2016

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Strojny, B., Grodzik, M., Sawosz, E., Winnicka, A., Kurantowicz, N., Jaworski, S., Kutwin, M., Urbanska, K., Hotowy, A., Wierzbicki, M., & Chwalibog, A. (2016). Diamond nanoparticles modity curcumin activity: in vitro studies on cancer and normal cells and in ovo studies on chicken embryo model. P L o S One, 11(10), Article e0164637. https://doi.org/10.1371/journal.pone.0164637

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abstract = "Curcumin has been studied broadly for its wide range of biological activities, including anticancer properties. The major problem with curcumin is its poor bioavailability, which can be improved by the addition of carriers, such as diamond nanoparticles (DN). They are carbon allotropes, and are therefore biocompatible and easily taken up by cells. DN are non-toxic and have antiangiogenic properties with potential applications in cancer therapy. Their large surface makes them promising compounds in a drug delivery system for bioactive agents, as DN create bio-complexes in a fast and simple process of self-organisation. We investigated the cytotoxicity of such bio-complexes against liver cancer cells and normal fibroblasts, revealing that conjugation of curcumin with DN significantly improves its activity. The experiment performed in a chicken embryo model demonstrated that neither curcumin nor DN nor bio-complexes affect embryo development, even though DN can form deposits in tissues. Preliminary results confirmed the applicability of DN as an efficient carrier of curcumin, which improves its performance against cancer cells in vitro, yet is not toxic to an organism, which makes the bio-complex a promising anticancer agent.",

author = "Barbara Strojny and Marta Grodzik and Ewa Sawosz and Anna Winnicka and Natalia Kurantowicz and Slawomir Jaworski and Marta Kutwin and Kaja Urbanska and Anna Hotowy and Mateusz Wierzbicki and Andr{\'e} Chwalibog",

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AU - Strojny, Barbara

AU - Grodzik, Marta

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AU - Winnicka, Anna

AU - Kurantowicz, Natalia

AU - Jaworski, Slawomir

AU - Kutwin, Marta

AU - Urbanska, Kaja

AU - Hotowy, Anna

AU - Wierzbicki, Mateusz

AU - Chwalibog, André

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N2 - Curcumin has been studied broadly for its wide range of biological activities, including anticancer properties. The major problem with curcumin is its poor bioavailability, which can be improved by the addition of carriers, such as diamond nanoparticles (DN). They are carbon allotropes, and are therefore biocompatible and easily taken up by cells. DN are non-toxic and have antiangiogenic properties with potential applications in cancer therapy. Their large surface makes them promising compounds in a drug delivery system for bioactive agents, as DN create bio-complexes in a fast and simple process of self-organisation. We investigated the cytotoxicity of such bio-complexes against liver cancer cells and normal fibroblasts, revealing that conjugation of curcumin with DN significantly improves its activity. The experiment performed in a chicken embryo model demonstrated that neither curcumin nor DN nor bio-complexes affect embryo development, even though DN can form deposits in tissues. Preliminary results confirmed the applicability of DN as an efficient carrier of curcumin, which improves its performance against cancer cells in vitro, yet is not toxic to an organism, which makes the bio-complex a promising anticancer agent.

AB - Curcumin has been studied broadly for its wide range of biological activities, including anticancer properties. The major problem with curcumin is its poor bioavailability, which can be improved by the addition of carriers, such as diamond nanoparticles (DN). They are carbon allotropes, and are therefore biocompatible and easily taken up by cells. DN are non-toxic and have antiangiogenic properties with potential applications in cancer therapy. Their large surface makes them promising compounds in a drug delivery system for bioactive agents, as DN create bio-complexes in a fast and simple process of self-organisation. We investigated the cytotoxicity of such bio-complexes against liver cancer cells and normal fibroblasts, revealing that conjugation of curcumin with DN significantly improves its activity. The experiment performed in a chicken embryo model demonstrated that neither curcumin nor DN nor bio-complexes affect embryo development, even though DN can form deposits in tissues. Preliminary results confirmed the applicability of DN as an efficient carrier of curcumin, which improves its performance against cancer cells in vitro, yet is not toxic to an organism, which makes the bio-complex a promising anticancer agent.

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Diamond nanoparticles modity curcumin activity: in vitro studies on cancer and normal cells and in ovo studies on chicken embryo model

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