TY - JOUR
T1 - Diagnostic values of fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase in hepatobiliary disease
AU - Linnet, K.
AU - Kelbæk, H.
AU - Bahnsen, M.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase were measured in 138 consecutive patients, 62 with (D) and 76 without (D) hepatobiliary disease. The maximum efficiencies of the three tests - that is, the fractions of patients allocated correctly to the D or D group at the optimum discrimination values - were 0.85, 0.84, and 0.83, respectively. Furthermore, the predictive values and nosographic sensitivities and specificities were rather similar. When the three tests were combined, the nosographic sensitivity increased significantly to a value of 0.84, and the corresponding specificity was 0.91. The diagnostic value of the absolute postprandial increase in serum bile acid concentration was slightly inferior to the diagnostic values of the fasting and postprandial serum bile acid concentrations and, finally, the relative postprandial serum bile acid increase was of no diagnostic value at all.
AB - Fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase were measured in 138 consecutive patients, 62 with (D) and 76 without (D) hepatobiliary disease. The maximum efficiencies of the three tests - that is, the fractions of patients allocated correctly to the D or D group at the optimum discrimination values - were 0.85, 0.84, and 0.83, respectively. Furthermore, the predictive values and nosographic sensitivities and specificities were rather similar. When the three tests were combined, the nosographic sensitivity increased significantly to a value of 0.84, and the corresponding specificity was 0.91. The diagnostic value of the absolute postprandial increase in serum bile acid concentration was slightly inferior to the diagnostic values of the fasting and postprandial serum bile acid concentrations and, finally, the relative postprandial serum bile acid increase was of no diagnostic value at all.
KW - 3αhydroxy-bile acids
KW - Diagnosis
KW - Gamma-glutamyl transferase
KW - Hepatobiliary disease
KW - Serum
UR - http://www.scopus.com/inward/record.url?scp=0020671683&partnerID=8YFLogxK
U2 - 10.3109/00365528309181558
DO - 10.3109/00365528309181558
M3 - Journal article
C2 - 6144169
AN - SCOPUS:0020671683
SN - 0085-5928
VL - 18
SP - 49
EP - 56
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
IS - 1
ER -