Diagnostic sensitivity and specificity of Doppler ultrasound in rheumatoid arthritis

L. Terslev; P. von der Recke; S. Torp-Pedersen; M.J. Koenig; H. Bliddal

Diagnostic sensitivity and specificity of Doppler ultrasound in rheumatoid arthritis

L. Terslev, P. von der Recke, S. Torp-Pedersen, M.J. Koenig, H. Bliddal

51 Citations (Scopus)

Abstract

Objective. To evaluate the sensitivity and specificity of Doppler ultrasound (DUS) in diagnosing arthritis in the wrist and hands, and, if possible, to define a cutoff level for our ultrasound measures for inflammation, resistive index (RI), and color fraction. Methods. Using DUS, 88 patients with active RA were selected for study and 27 healthy controls. A total of 419 joints were examined. The synovial vascularization was determined by color Doppler and spectral Doppler estimating the color fraction (the percentage of color pixels inside the synovium was the region of interest) and RI in wrist, metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints. Receiver-operator characteristic (ROC) curves were made for both US measures. Cutoff levels were selected from the ROC curves as the values with the optimum sensitivity and specificity. Results. Analyses were carried out for small joints (MCP and PIP), wrists, and for all joints (pooled). Pooled joint analysis showed the area under the curve for both RI and color fraction was 0.84. The cutoff level for the color fraction was 0.01 and for RI 0.83. With these cutoff levels, the sensitivity and specificity for the color fraction were 0.92 and 0.73, respectively. For RI a sensitivity of 0.72 and specificity of 0.70 were found. Analysis of small joints and wrist gave very similar results. Conclusion. DUS may detect vascularization of the inflamed synovium with a high sensitivity and a moderate specificity with selected cutoff levels
Udgivelsesdato: 2008/1

Original language	English
Journal	Journal of Rheumatology
Volume	35
Issue number	1
Pages (from-to)	49-53
Number of pages	4
ISSN	0315-162X
Publication status	Published - 2008

Cite this

@article{76954250f84811ddb219000ea68e967b,

title = "Diagnostic sensitivity and specificity of Doppler ultrasound in rheumatoid arthritis",

abstract = "Objective. To evaluate the sensitivity and specificity of Doppler ultrasound (DUS) in diagnosing arthritis in the wrist and hands, and, if possible, to define a cutoff level for our ultrasound measures for inflammation, resistive index (RI), and color fraction. Methods. Using DUS, 88 patients with active RA were selected for study and 27 healthy controls. A total of 419 joints were examined. The synovial vascularization was determined by color Doppler and spectral Doppler estimating the color fraction (the percentage of color pixels inside the synovium was the region of interest) and RI in wrist, metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints. Receiver-operator characteristic (ROC) curves were made for both US measures. Cutoff levels were selected from the ROC curves as the values with the optimum sensitivity and specificity. Results. Analyses were carried out for small joints (MCP and PIP), wrists, and for all joints (pooled). Pooled joint analysis showed the area under the curve for both RI and color fraction was 0.84. The cutoff level for the color fraction was 0.01 and for RI 0.83. With these cutoff levels, the sensitivity and specificity for the color fraction were 0.92 and 0.73, respectively. For RI a sensitivity of 0.72 and specificity of 0.70 were found. Analysis of small joints and wrist gave very similar results. Conclusion. DUS may detect vascularization of the inflamed synovium with a high sensitivity and a moderate specificity with selected cutoff levels Udgivelsesdato: 2008/1",

author = "L. Terslev and Recke, {P. von der} and S. Torp-Pedersen and M.J. Koenig and H. Bliddal",

note = "Times Cited: 0ArticleEnglishTerslev, LFrederiksberg Univ Hosp, Dept Rheumatol, Parker Inst, DK-2000 Frederiksberg, DenmarkCited References Count: 27249UOJ RHEUMATOL PUBL CO920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADATORONTO",

year = "2008",

language = "English",

volume = "35",

pages = "49--53",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology Publishing Co. Ltd.",

number = "1",

}

TY - JOUR

T1 - Diagnostic sensitivity and specificity of Doppler ultrasound in rheumatoid arthritis

AU - Terslev, L.

AU - Recke, P. von der

AU - Torp-Pedersen, S.

AU - Koenig, M.J.

AU - Bliddal, H.

N1 - Times Cited: 0ArticleEnglishTerslev, LFrederiksberg Univ Hosp, Dept Rheumatol, Parker Inst, DK-2000 Frederiksberg, DenmarkCited References Count: 27249UOJ RHEUMATOL PUBL CO920 YONGE ST, SUITE 115, TORONTO, ONTARIO M4W 3C7, CANADATORONTO

PY - 2008

Y1 - 2008

N2 - Objective. To evaluate the sensitivity and specificity of Doppler ultrasound (DUS) in diagnosing arthritis in the wrist and hands, and, if possible, to define a cutoff level for our ultrasound measures for inflammation, resistive index (RI), and color fraction. Methods. Using DUS, 88 patients with active RA were selected for study and 27 healthy controls. A total of 419 joints were examined. The synovial vascularization was determined by color Doppler and spectral Doppler estimating the color fraction (the percentage of color pixels inside the synovium was the region of interest) and RI in wrist, metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints. Receiver-operator characteristic (ROC) curves were made for both US measures. Cutoff levels were selected from the ROC curves as the values with the optimum sensitivity and specificity. Results. Analyses were carried out for small joints (MCP and PIP), wrists, and for all joints (pooled). Pooled joint analysis showed the area under the curve for both RI and color fraction was 0.84. The cutoff level for the color fraction was 0.01 and for RI 0.83. With these cutoff levels, the sensitivity and specificity for the color fraction were 0.92 and 0.73, respectively. For RI a sensitivity of 0.72 and specificity of 0.70 were found. Analysis of small joints and wrist gave very similar results. Conclusion. DUS may detect vascularization of the inflamed synovium with a high sensitivity and a moderate specificity with selected cutoff levels Udgivelsesdato: 2008/1

AB - Objective. To evaluate the sensitivity and specificity of Doppler ultrasound (DUS) in diagnosing arthritis in the wrist and hands, and, if possible, to define a cutoff level for our ultrasound measures for inflammation, resistive index (RI), and color fraction. Methods. Using DUS, 88 patients with active RA were selected for study and 27 healthy controls. A total of 419 joints were examined. The synovial vascularization was determined by color Doppler and spectral Doppler estimating the color fraction (the percentage of color pixels inside the synovium was the region of interest) and RI in wrist, metacarpophalangeal (MCP), and proximal interphalangeal (PIP) joints. Receiver-operator characteristic (ROC) curves were made for both US measures. Cutoff levels were selected from the ROC curves as the values with the optimum sensitivity and specificity. Results. Analyses were carried out for small joints (MCP and PIP), wrists, and for all joints (pooled). Pooled joint analysis showed the area under the curve for both RI and color fraction was 0.84. The cutoff level for the color fraction was 0.01 and for RI 0.83. With these cutoff levels, the sensitivity and specificity for the color fraction were 0.92 and 0.73, respectively. For RI a sensitivity of 0.72 and specificity of 0.70 were found. Analysis of small joints and wrist gave very similar results. Conclusion. DUS may detect vascularization of the inflamed synovium with a high sensitivity and a moderate specificity with selected cutoff levels Udgivelsesdato: 2008/1

M3 - Journal article

SN - 0315-162X

VL - 35

SP - 49

EP - 53

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 1

ER -