Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study

Andrea L Vavere; Gregory G Simon; Richard T George; Carlos E Rochitte; Andrew E Arai; Julie M Miller; Marcello Di Carli; Armin Arbab-Zadeh; Armin A Zadeh; Marc Dewey; Hiroyuki Niinuma; Roger Laham; Frank J Rybicki; Joanne D Schuijf; Narinder Paul; John Hoe; Sachio Kuribyashi; Hajime Sakuma; Cesar Nomura; Tan Swee Yaw; Klaus F Kofoed; Kunihiro Yoshioka; Melvin E Clouse; Jeffrey Brinker; Christopher Cox; Joao A C Lima

doi:10.1016/j.jcct.2011.11.001

Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study

Andrea L Vavere, Gregory G Simon, Richard T George, Carlos E Rochitte, Andrew E Arai, Julie M Miller, Marcello Di Carli, Armin Arbab-Zadeh, Armin A Zadeh, Marc Dewey, Hiroyuki Niinuma, Roger Laham, Frank J Rybicki, Joanne D Schuijf, Narinder Paul, John Hoe, Sachio Kuribyashi, Hajime Sakuma, Cesar Nomura, Tan Swee YawKlaus F Kofoed, Kunihiro Yoshioka, Melvin E Clouse, Jeffrey Brinker, Christopher Cox, Joao A C Lima

63 Citations (Scopus)

Abstract

Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

Original language	English
Journal	Journal of Cardiovascular Computed Tomography
Volume	5
Issue number	6
Pages (from-to)	370-81
Number of pages	12
ISSN	1934-5925
DOIs	https://doi.org/10.1016/j.jcct.2011.11.001
Publication status	Published - Nov 2011

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Vavere, A. L., Simon, G. G., George, R. T., Rochitte, C. E., Arai, A. E., Miller, J. M., Di Carli, M., Arbab-Zadeh, A., Zadeh, A. A., Dewey, M., Niinuma, H., Laham, R., Rybicki, F. J., Schuijf, J. D., Paul, N., Hoe, J., Kuribyashi, S., Sakuma, H., Nomura, C., ... Lima, J. A. C. (2011). Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study. Journal of Cardiovascular Computed Tomography, 5(6), 370-81. https://doi.org/10.1016/j.jcct.2011.11.001

Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography : design and implementation of the CORE320 multicenter, multinational diagnostic study. / Vavere, Andrea L; Simon, Gregory G; George, Richard T et al.

In: Journal of Cardiovascular Computed Tomography, Vol. 5, No. 6, 11.2011, p. 370-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Vavere, AL, Simon, GG, George, RT, Rochitte, CE, Arai, AE, Miller, JM, Di Carli, M, Arbab-Zadeh, A, Zadeh, AA, Dewey, M, Niinuma, H, Laham, R, Rybicki, FJ, Schuijf, JD, Paul, N, Hoe, J, Kuribyashi, S, Sakuma, H, Nomura, C, Yaw, TS, Kofoed, KF, Yoshioka, K, Clouse, ME, Brinker, J, Cox, C & Lima, JAC 2011, 'Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study', Journal of Cardiovascular Computed Tomography, vol. 5, no. 6, pp. 370-81. https://doi.org/10.1016/j.jcct.2011.11.001

Vavere AL, Simon GG, George RT, Rochitte CE, Arai AE, Miller JM et al. Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography: design and implementation of the CORE320 multicenter, multinational diagnostic study. Journal of Cardiovascular Computed Tomography. 2011 Nov;5(6):370-81. doi: 10.1016/j.jcct.2011.11.001

Vavere, Andrea L ; Simon, Gregory G ; George, Richard T et al. / Diagnostic performance of combined noninvasive coronary angiography and myocardial perfusion imaging using 320 row detector computed tomography : design and implementation of the CORE320 multicenter, multinational diagnostic study. In: Journal of Cardiovascular Computed Tomography. 2011 ; Vol. 5, No. 6. pp. 370-81.

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abstract = "Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ({"}Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography{"}). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.",

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AU - George, Richard T

AU - Rochitte, Carlos E

AU - Arai, Andrew E

AU - Miller, Julie M

AU - Di Carli, Marcello

AU - Arbab-Zadeh, Armin

AU - Zadeh, Armin A

AU - Dewey, Marc

AU - Niinuma, Hiroyuki

AU - Laham, Roger

AU - Rybicki, Frank J

AU - Schuijf, Joanne D

AU - Paul, Narinder

AU - Hoe, John

AU - Kuribyashi, Sachio

AU - Sakuma, Hajime

AU - Nomura, Cesar

AU - Yaw, Tan Swee

AU - Kofoed, Klaus F

AU - Yoshioka, Kunihiro

AU - Clouse, Melvin E

AU - Brinker, Jeffrey

AU - Cox, Christopher

AU - Lima, Joao A C

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N2 - Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

AB - Multidetector coronary computed tomography angiography (CTA) is a promising modality for widespread clinical application because of its noninvasive nature and high diagnostic accuracy as found in previous studies using 64 to 320 simultaneous detector rows. It is, however, limited in its ability to detect myocardial ischemia. In this article, we describe the design of the CORE320 study ("Combined coronary atherosclerosis and myocardial perfusion evaluation using 320 detector row computed tomography"). This prospective, multicenter, multinational study is unique in that it is designed to assess the diagnostic performance of combined 320-row CTA and myocardial CT perfusion imaging (CTP) in comparison with the combination of invasive coronary angiography and single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI). The trial is being performed at 16 medical centers located in 8 countries worldwide. CT has the potential to assess both anatomy and physiology in a single imaging session. The co-primary aim of the CORE320 study is to define the per-patient diagnostic accuracy of the combination of coronary CTA and myocardial CTP to detect physiologically significant coronary artery disease compared with (1) the combination of conventional coronary angiography and SPECT-MPI and (2) conventional coronary angiography alone. If successful, the technology could revolutionize the management of patients with symptomatic CAD.

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