Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients

Carsten L Fagö-Olsen; Fanny Håkansson; Sofie L Antonsen; Estrid Høgdall; Lene Lundvall; Lotte Nedergaard; Svend A Engelholm; Claus Høgdall

doi:10.1111/aogs.12127

Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients

Carsten L Fagö-Olsen, Fanny Håkansson, Sofie L Antonsen, Estrid Høgdall, Lene Lundvall, Lotte Nedergaard, Svend A Engelholm, Claus Høgdall

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk of malignancy index (RMI) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, 49 of whom had no residual tumor after PDS. The receiver operating characteristic curve showed an area under the curve of 0.72 (confidence interval: 0.64-0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS, but no single cut-off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine whether complete tumor removal is possible with PDS.

Original language	English
Journal	Acta Obstetricia et Gynecologica Scandinavica
Volume	92
Issue number	6
Pages (from-to)	721-726
Number of pages	6
ISSN	0001-6349
DOIs	https://doi.org/10.1111/aogs.12127
Publication status	Published - Jun 2013

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Fagö-Olsen, C. L., Håkansson, F., Antonsen, S. L., Høgdall, E., Lundvall, L., Nedergaard, L., Engelholm, S. A., & Høgdall, C. (2013). Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients. Acta Obstetricia et Gynecologica Scandinavica, 92(6), 721-726. https://doi.org/10.1111/aogs.12127

Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients. / Fagö-Olsen, Carsten L; Håkansson, Fanny; Antonsen, Sofie L et al.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 92, No. 6, 06.2013, p. 721-726.

Research output: Contribution to journal › Journal article › Research › peer-review

Fagö-Olsen, CL, Håkansson, F, Antonsen, SL, Høgdall, E, Lundvall, L, Nedergaard, L, Engelholm, SA & Høgdall, C 2013, 'Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients', Acta Obstetricia et Gynecologica Scandinavica, vol. 92, no. 6, pp. 721-726. https://doi.org/10.1111/aogs.12127

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abstract = "Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk of malignancy index (RMI) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, 49 of whom had no residual tumor after PDS. The receiver operating characteristic curve showed an area under the curve of 0.72 (confidence interval: 0.64-0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS, but no single cut-off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine whether complete tumor removal is possible with PDS.",

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AU - Håkansson, Fanny

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AU - Høgdall, Estrid

AU - Lundvall, Lene

AU - Nedergaard, Lotte

AU - Engelholm, Svend A

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AB - Ovarian cancer patients in whom complete tumor removal is impossible with primary debulking surgery (PDS) may benefit from neoadjuvant chemotherapy and interval debulking surgery. However, the task of performing a pre-operative evaluation of the feasibility of PDS is difficult. We aimed to investigate whether the risk of malignancy index (RMI) was a useful marker for this evaluation. RMI and surgical outcome were investigated in 164 patients, 49 of whom had no residual tumor after PDS. The receiver operating characteristic curve showed an area under the curve of 0.72 (confidence interval: 0.64-0.80). The possibility of complete tumor removal decreased with increasing RMI and there was a tendency towards higher RMI in patients with residual tumor after PDS, but no single cut-off value of RMI produced useful clinical predictive values. In conclusion, RMI alone is not an optimal method to determine whether complete tumor removal is possible with PDS.

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Diagnostic accuracy of risk of malignancy index in predicting complete tumor removal at primary debulking surgery for ovarian cancer patients

Abstract

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