Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10

L A van Pinxteren; P Ravn; E M Agger; J Pollock; P Andersen

Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10

L A van Pinxteren, P Ravn, E M Agger, J Pollock, P Andersen

288 Citations (Scopus)

Abstract

Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of two Mycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).

Original language	English
Journal	Clinical and Vaccine Immunology
Volume	7
Issue number	2
Pages (from-to)	155-60
Number of pages	5
ISSN	1556-6811
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{62f76f7135e14287a304f1bc6a6e8339,

title = "Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10",

abstract = "Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of two Mycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).",

author = "{van Pinxteren}, {L A} and P Ravn and Agger, {E M} and J Pollock and P Andersen",

year = "2000",

language = "English",

volume = "7",

pages = "155--60",

journal = "Clinical and Vaccine Immunology",

issn = "1556-6811",

publisher = "American Society for Microbiology",

number = "2",

}

TY - JOUR

T1 - Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10

AU - van Pinxteren, L A

AU - Ravn, P

AU - Agger, E M

AU - Pollock, J

AU - Andersen, P

PY - 2000

Y1 - 2000

N2 - Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of two Mycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).

AB - Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental mycobacteria. The present study investigated the diagnostic potential of two Mycobacterium tuberculosis-specific antigens (ESAT-6 and CFP10) in experimental animals as well as during natural infection in humans and cattle. Both antigens were frequently recognized in vivo and in vitro based on the induction of delayed-type hypersensitivity responses and the ability to induce gamma interferon production by lymphocytes, respectively. The combination of ESAT-6 and CFP10 was found to be highly sensitive and specific for both in vivo and in vitro diagnosis. In humans, the combination had a high sensitivity (73%) and a much higher specificity (93%) than PPD (7%).

M3 - Journal article

SN - 1556-6811

VL - 7

SP - 155

EP - 160

JO - Clinical and Vaccine Immunology

JF - Clinical and Vaccine Immunology

IS - 2

ER -

Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10

Abstract

UN SDGs

Fingerprint

Cite this