Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

Karsten Buschard; Katrin Thomassen; Elsebeth Lynge; Ilse Vejborg; Anne Tjønneland; My von Euler-Chelpin; Zorana Jovanovic Andersen

doi:10.1007/s10552-016-0829-z

Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

Karsten Buschard, Katrin Thomassen, Elsebeth Lynge, Ilse Vejborg, Anne Tjønneland, My von Euler-Chelpin, Zorana Jovanovic Andersen

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Abstract

PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.

METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.

RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.

CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.

Original language	English
Journal	Cancer Causes & Control
Volume	28
Issue number	1
Pages (from-to)	13–21
Number of pages	9
ISSN	0957-5243
DOIs	https://doi.org/10.1007/s10552-016-0829-z
Publication status	Published - 1 Jan 2017

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@article{1b75a4de11e2447eb9453999570ce250,

title = "Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort",

abstract = "PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.",

author = "Karsten Buschard and Katrin Thomassen and Elsebeth Lynge and Ilse Vejborg and Anne Tj{\o}nneland and {von Euler-Chelpin}, My and Andersen, {Zorana Jovanovic}",

year = "2017",

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day = "1",

doi = "10.1007/s10552-016-0829-z",

language = "English",

volume = "28",

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journal = "Cancer Causes & Control",

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TY - JOUR

T1 - Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

AU - Buschard, Karsten

AU - Thomassen, Katrin

AU - Lynge, Elsebeth

AU - Vejborg, Ilse

AU - Tjønneland, Anne

AU - von Euler-Chelpin, My

AU - Andersen, Zorana Jovanovic

PY - 2017/1/1

Y1 - 2017/1/1

N2 - PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.

AB - PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years.METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997). The association between MD and diabetes was analyzed by logistic regression adjusted for potential confounders. Effect modification by menopausal status and body mass index (BMI) was performed by introducing an interaction term into the model and tested by Wald test.RESULTS: Of 5,644 women with mean age of 56 years, 137 (2.4%) had diabetes and 3,180 (56.3%) had mixed/dense breasts. Having diabetes was significantly inversely associated with having mixed/dense breasts, in both, the crude model (odds ratio; 95% confidence interval: 0.33; 0.23-0.48), and after adjustment for adiposity and other risk factors (0.61; 0.40-0.92). Similar inverse associations were observed for 44 women who controlled diabetes by diet only and did not receive any medication (0.56; 0.27-1.14), and 62 who took oral antidiabetic agents only for diabetes (0.59; 0.32-1.09), while women taking insulin had increased odds of mixed/dense breasts (2.08; 0.68-6.35). There was no effect modification of these associations by menopausal status or BMI.CONCLUSIONS: Having diabetes controlled by diet or oral antidiabetic agents is associated with a decrease in MD, whereas taking insulin is associated with an increase in MD.

U2 - 10.1007/s10552-016-0829-z

DO - 10.1007/s10552-016-0829-z

M3 - Journal article

C2 - 27832382

SN - 0957-5243

VL - 28

SP - 13

EP - 21

JO - Cancer Causes & Control

JF - Cancer Causes & Control

IS - 1

ER -

Diabetes, diabetes treatment, and mammographic density in Danish Diet, Cancer, and Health cohort

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