Abstract
Parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) regulate calcium homeostasis, and PTHrP further regulates growth and development. A transgenic mouse carrying the constitutively active PTH/PTHrP receptor (HKrk-H223R) under the control of the mouse bone and odontoblast-specific alpha1(I) collagen promoter (Col1-caPPR) has been developed to demonstrate the complex actions of this mutant receptor in hard tissue formation. We have further characterized Col1-caPPR mice abnormalities in the craniofacial region as a function of development. Col1-caPPR mice exhibited a delay in embryonic bone formation, followed by expansion of a number of craniofacial bones including the maxilla and mandible, delay in tooth eruption and teratosis, and a disrupted temporomandibular joint (TMJ). These findings suggest that the Col1-caPPR mouse is a useful model for characterization of the downstream effects of the constitutively active receptor during development and growth, and as a model for development of treatments of human diseases with similar characteristics.
| Original language | English |
|---|---|
| Journal | Bone |
| Volume | 42 |
| Issue number | 2 |
| Pages (from-to) | 321-31 |
| Number of pages | 11 |
| ISSN | 8756-3282 |
| DOIs | |
| Publication status | Published - Feb 2008 |
Keywords
- Animals
- Collagen Type I/genetics
- Embryo, Mammalian/diagnostic imaging
- Facial Bones/diagnostic imaging
- Female
- Male
- Mice
- Mice, Transgenic
- Microscopy, Electron, Scanning
- Parathyroid Hormone/genetics
- Promoter Regions, Genetic/genetics
- Tomography, X-Ray Computed
