Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1

Rikke Andersen; Flemming Steen Jørgensen; Lars Olsen; Jon Våbenø; Karina Thorn; Carsten Uhd Nielsen; Bente Steffansen

doi:10.1007/s11095-006-9462-y

Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1

Rikke Andersen, Flemming Steen Jørgensen, Lars Olsen, Jon Våbenø, Karina Thorn, Carsten Uhd Nielsen, Bente Steffansen

15 Citations (Scopus)

Abstract

The aim of this study was to develop a three-dimensional quantitative structure-activity relationship (QSAR) model for binding of tripeptides and tripeptidomimetics to hPEPT1 based on a series of 25 diverse tripeptides.

Original language	English
Journal	Pharmaceutical Research
Volume	23
Issue number	3
Pages (from-to)	483-92
Number of pages	10
ISSN	0724-8741
DOIs	https://doi.org/10.1007/s11095-006-9462-y
Publication status	Published - 2006

Keywords

Caco-2 Cells
Drug Design
Humans
Intestinal Mucosa
Models, Biological
Peptides
Protein Binding
Protein Conformation
Quantitative Structure-Activity Relationship
Symporters

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10.1007/s11095-006-9462-y

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abstract = "The aim of this study was to develop a three-dimensional quantitative structure-activity relationship (QSAR) model for binding of tripeptides and tripeptidomimetics to hPEPT1 based on a series of 25 diverse tripeptides.",

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AU - Andersen, Rikke

AU - Jørgensen, Flemming Steen

AU - Olsen, Lars

AU - Våbenø, Jon

AU - Thorn, Karina

AU - Nielsen, Carsten Uhd

AU - Steffansen, Bente

PY - 2006

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N2 - The aim of this study was to develop a three-dimensional quantitative structure-activity relationship (QSAR) model for binding of tripeptides and tripeptidomimetics to hPEPT1 based on a series of 25 diverse tripeptides.

AB - The aim of this study was to develop a three-dimensional quantitative structure-activity relationship (QSAR) model for binding of tripeptides and tripeptidomimetics to hPEPT1 based on a series of 25 diverse tripeptides.

KW - Caco-2 Cells

KW - Drug Design

KW - Humans

KW - Intestinal Mucosa

KW - Models, Biological

KW - Peptides

KW - Protein Binding

KW - Protein Conformation

KW - Quantitative Structure-Activity Relationship

KW - Symporters

U2 - 10.1007/s11095-006-9462-y

DO - 10.1007/s11095-006-9462-y

M3 - Journal article

C2 - 16489544

SN - 0724-8741

VL - 23

SP - 483

EP - 492

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 3

ER -

Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1

Abstract

Keywords

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