Development in incidence of breast cancer in non-screened Danish women, 1973-2002--a population-based study

TY - JOUR

T1 - Development in incidence of breast cancer in non-screened Danish women, 1973-2002--a population-based study

AU - Fuglede, Niels

AU - Langballe, Oline

AU - Svendsen, Anne Louise

AU - Tjønneland, Anne

AU - Dalton, Susanne O

AU - Johansen, Christoffer

N1 - Keywords: Age Factors; Aged; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cohort Studies; Denmark; Female; Humans; Incidence; Mass Screening; Menopause; Middle Aged; Registries

PY - 2006

Y1 - 2006

N2 - The authors report on the incidence rates of breast cancer overall and by histology in a population of unscreened women constituting approximately 80% of the total population of women in Denmark from 1973-2002, utilizing the files of the nationwide Danish Cancer Registry. The age-specific incidence rates of breast cancer increased throughout the period, and further, marked changes in the age-specific incidence pattern were observed, where the plateau and change of slope around the age of 46-48 in 1973-1981 shifted to around age 64-66 years in 1994-2002. Age-period-cohort modeling indicated that these changes were not attributable to a birth cohort effect. Although lobular breast cancer incidence increased more than ductal breast cancer incidence, this was only observed in the first decade after the introduction of the ICD-O system in Denmark and probably is attributable to this, whereas we observed no disproportionate changes by histology in any age group from 1988-2002. Thus, previous reports of a disproportionate increase in lobular breast cancer could not be confirmed in a non-screened population, whereas important changes over the past decade in the age-specific incidence pattern of breast cancer particular around the time of menopause were indicated.

AB - The authors report on the incidence rates of breast cancer overall and by histology in a population of unscreened women constituting approximately 80% of the total population of women in Denmark from 1973-2002, utilizing the files of the nationwide Danish Cancer Registry. The age-specific incidence rates of breast cancer increased throughout the period, and further, marked changes in the age-specific incidence pattern were observed, where the plateau and change of slope around the age of 46-48 in 1973-1981 shifted to around age 64-66 years in 1994-2002. Age-period-cohort modeling indicated that these changes were not attributable to a birth cohort effect. Although lobular breast cancer incidence increased more than ductal breast cancer incidence, this was only observed in the first decade after the introduction of the ICD-O system in Denmark and probably is attributable to this, whereas we observed no disproportionate changes by histology in any age group from 1988-2002. Thus, previous reports of a disproportionate increase in lobular breast cancer could not be confirmed in a non-screened population, whereas important changes over the past decade in the age-specific incidence pattern of breast cancer particular around the time of menopause were indicated.

U2 - 10.1002/ijc.21654

DO - 10.1002/ijc.21654

M3 - Journal article

C2 - 16331626

SN - 0020-7136

VL - 118

SP - 2366

EP - 2369

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 9

ER -