TY - JOUR
T1 - Development and validation of an OMERACT MRI whole-body score for inflammation in peripheral joints and entheses in inflammatory arthritis (MRI-WIPE)
AU - Krabbe, Simon
AU - Eshed, Iris
AU - Gandjbakhch, Frédérique
AU - Pedersen, Susanne J.
AU - Bird, Paul
AU - Mathew, Ashish J.
AU - Lambert, Robert G.
AU - Maksymowych, Walter P.
AU - Glinatsi, Daniel
AU - Stoenoiu, Maria S.
AU - Poggenborg, René
AU - Jans, Lennart
AU - Jaremko, Jacob L.
AU - Herregods, Nele
AU - Foltz, Violaine
AU - Conaghan, Philip G.
AU - Althoff, Christian E.
AU - Paschke, Joel
AU - Peterfy, Charles
AU - Hermann, Kay Geert A.
AU - Østergaard, Mikkel
AU - for the OMERACT MRI in Arthritis Working Group
PY - 2019
Y1 - 2019
N2 - Objective. To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. Methods.After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. Results. In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κranged 0.35-0.77. Conclusion. Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
AB - Objective. To develop a whole-body magnetic resonance imaging (MRI) scoring system for peripheral arthritis and enthesitis. Methods.After consensus on definitions/locations of MRI pathologies, 4 multireader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, and 33 entheses 0-3 separately for soft tissue inflammation and osteitis. Results. In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICC were 0.67/0.80 for status scores and 0.69/0.82 for change scores; κranged 0.35-0.77. Conclusion. Whole-body MRI scoring of peripheral arthritis and enthesitis is reliable, which encourages further testing and refinement in clinical trials.
KW - Arthritis
KW - Magnetic resonance imaging
KW - Omeract
KW - Outcome assessment
U2 - 10.3899/jrheum.181084
DO - 10.3899/jrheum.181084
M3 - Journal article
C2 - 30770508
AN - SCOPUS:85071783201
SN - 0315-162X
VL - 46
SP - 1215
EP - 1221
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 9
ER -