Development and aging of human spinal cord circuitries

Svend Sparre Geertsen, Maria Willerslev-Olsen, Jakob Lorentzen, Jens Bo Nielsen

9 Citations (Scopus)

Abstract

The neural motor circuitries in the spinal cord receive information from our senses and the rest of the nervous system and translate it into purposeful movements, which allow us to interact with the rest of the world. In this review, we discuss how these circuitries are established during early development and the extent to which they are shaped according to the demands of the body that they control and the environment with which the body has to interact. We also discuss how aging processes and physiological changes in our body are reflected in adaptations of activity in the spinal cord motor circuitries. The complex, multifaceted connectivity of the spinal cord motor circuitries allows them to generate vastly different movements and to adapt their activity to meet new challenges imposed by bodily changes or a changing environment. There are thus plenty of possibilities for adaptive changes in the spinal motor circuitries both early and late in life.

Original languageEnglish
JournalJournal of Neurophysiology
Volume118
Issue number2
Pages (from-to)1133-1140
Number of pages8
ISSN0022-3077
DOIs
Publication statusPublished - 4 Aug 2017

Keywords

  • Faculty of Science
  • Spinal cord
  • Reflexes
  • Aging
  • Motor control
  • Development

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