Determination of thirteen antibiotics in drug products – A new LC-MS/MS tool for screening drug product quality

Samuel Oppong Bekoe; Søren Alex Bak; Erland Björklund; Kristine Andersen Krogh; Nathaniel N. Okine; Reimmiel K. Adorsraku; Bjarne Styrishave; Martin Hansen

Determination of thirteen antibiotics in drug products – A new LC-MS/MS tool for screening drug product quality

Samuel Oppong Bekoe, Søren Alex Bak, Erland Björklund, Kristine Andersen Krogh, Nathaniel N. Okine, Reimmiel K. Adorsraku, Bjarne Styrishave, Martin Hansen

8 Citations (Scopus)

Abstract

Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

Original language	English
Journal	Analytical Methods
Volume	6
Pages (from-to)	5847-5855
ISSN	1759-9660
Publication status	Published - 7 Aug 2014

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title = "Determination of thirteen antibiotics in drug products – A new LC-MS/MS tool for screening drug product quality",

abstract = "Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.",

author = "Bekoe, {Samuel Oppong} and Bak, {S{\o}ren Alex} and Erland Bj{\"o}rklund and Krogh, {Kristine Andersen} and Okine, {Nathaniel N.} and Adorsraku, {Reimmiel K.} and Bjarne Styrishave and Martin Hansen",

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T1 - Determination of thirteen antibiotics in drug products – A new LC-MS/MS tool for screening drug product quality

AU - Bekoe, Samuel Oppong

AU - Bak, Søren Alex

AU - Björklund, Erland

AU - Krogh, Kristine Andersen

AU - Okine, Nathaniel N.

AU - Adorsraku, Reimmiel K.

AU - Styrishave, Bjarne

AU - Hansen, Martin

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

AB - Poor quality antibiotic medicines in circulation in Sub-Saharan Africa continue to be a burden. Pharmaceutical trade in substandard and counterfeit medicines is on the rise. The chemical quality of antibiotics dispensed in health facilities and recognised drug outlets in Ghana, when compromised, could be a major drawback to efforts made in fighting antibiotic resistance globally. To improve on antibiotic drug quality monitoring, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology, which is capable of quantifying thirteen antibiotics in drug products, was developed and validated in present work. The methodology was applied to various drug products including tablets, capsules, suspensions, syrups, intravenous and injection solutions as well as ear and eye droplets used as essential medicines in a Sub-Saharan country, Ghana.

M3 - Journal article

SN - 1759-9660

VL - 6

SP - 5847

EP - 5855

JO - Analytical Methods

JF - Analytical Methods

ER -

Determination of thirteen antibiotics in drug products – A new LC-MS/MS tool for screening drug product quality

Abstract

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