Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

Stefan Ropele; Iris D Kilsdonk; Mike P Wattjes; Christian Langkammer; Wolter L de Graaf; Jette L Frederiksen; Henrik B Larsson; Marios Yiannakas; Claudia Am Wheeler-Kingshott; Christian Enzinger; Michael Khalil; Maria A Rocca; Till Sprenger; Michael Amann; Ludwig Kappos; Massimo Filippi; Alex Rovira; Olga Ciccarelli; Frederik Barkhof; Franz Fazekas

doi:10.1177/1352458514531085

Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

Stefan Ropele, Iris D Kilsdonk, Mike P Wattjes, Christian Langkammer, Wolter L de Graaf, Jette L Frederiksen, Henrik B Larsson, Marios Yiannakas, Claudia Am Wheeler-Kingshott, Christian Enzinger, Michael Khalil, Maria A Rocca, Till Sprenger, Michael Amann, Ludwig Kappos, Massimo Filippi, Alex Rovira, Olga Ciccarelli, Frederik Barkhof, Franz Fazekas

Department of Clinical Medicine

38 Citations (Scopus)

Abstract

BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.

SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.

RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.

CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.

Original language	English
Journal	Multiple Sclerosis
Volume	20
Issue number	13
Pages (from-to)	1692-1698
Number of pages	7
ISSN	1352-4585
DOIs	https://doi.org/10.1177/1352458514531085
Publication status	Published - 20 Nov 2014

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Ropele, S., Kilsdonk, I. D., Wattjes, M. P., Langkammer, C., de Graaf, W. L., Frederiksen, J. L., Larsson, H. B., Yiannakas, M., Wheeler-Kingshott, C. A., Enzinger, C., Khalil, M., Rocca, M. A., Sprenger, T., Amann, M., Kappos, L., Filippi, M., Rovira, A., Ciccarelli, O., Barkhof, F., & Fazekas, F. (2014). Determinants of iron accumulation in deep grey matter of multiple sclerosis patients. Multiple Sclerosis, 20(13), 1692-1698. https://doi.org/10.1177/1352458514531085

Ropele, S, Kilsdonk, ID, Wattjes, MP, Langkammer, C, de Graaf, WL, Frederiksen, JL, Larsson, HB, Yiannakas, M, Wheeler-Kingshott, CA, Enzinger, C, Khalil, M, Rocca, MA, Sprenger, T, Amann, M, Kappos, L, Filippi, M, Rovira, A, Ciccarelli, O, Barkhof, F & Fazekas, F 2014, 'Determinants of iron accumulation in deep grey matter of multiple sclerosis patients', Multiple Sclerosis, vol. 20, no. 13, pp. 1692-1698. https://doi.org/10.1177/1352458514531085

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title = "Determinants of iron accumulation in deep grey matter of multiple sclerosis patients",

abstract = "BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.",

author = "Stefan Ropele and Kilsdonk, {Iris D} and Wattjes, {Mike P} and Christian Langkammer and {de Graaf}, {Wolter L} and Frederiksen, {Jette L} and Larsson, {Henrik B} and Marios Yiannakas and Wheeler-Kingshott, {Claudia Am} and Christian Enzinger and Michael Khalil and Rocca, {Maria A} and Till Sprenger and Michael Amann and Ludwig Kappos and Massimo Filippi and Alex Rovira and Olga Ciccarelli and Frederik Barkhof and Franz Fazekas",

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doi = "10.1177/1352458514531085",

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T1 - Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

AU - Ropele, Stefan

AU - Kilsdonk, Iris D

AU - Wattjes, Mike P

AU - Langkammer, Christian

AU - de Graaf, Wolter L

AU - Frederiksen, Jette L

AU - Larsson, Henrik B

AU - Yiannakas, Marios

AU - Wheeler-Kingshott, Claudia Am

AU - Enzinger, Christian

AU - Khalil, Michael

AU - Rocca, Maria A

AU - Sprenger, Till

AU - Amann, Michael

AU - Kappos, Ludwig

AU - Filippi, Massimo

AU - Rovira, Alex

AU - Ciccarelli, Olga

AU - Barkhof, Frederik

AU - Fazekas, Franz

PY - 2014/11/20

Y1 - 2014/11/20

N2 - BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.

AB - BACKGROUND: Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping.SUBJECTS AND METHODS: Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2* mapping was performed on 3T MRI systems. R2*in deep GM was corrected for age and was related to disease duration, disability, T2 lesion load and brain volume.RESULTS: Compared to controls, R2* was increased in all deep GM regions of MS patients except the globus pallidus and the substantia nigra. R2* increase was most pronounced in the progressive stage of the disease and independently predicted by disease duration and disability. Reduced cortical volume was not associated with iron accumulation in the deep GM with the exception of the substantia nigra and the red nucleus. In lesions, R2* was inversely correlated with disease duration and higher total lesion load.CONCLUSION: Iron accumulation in deep GM of MS patients is most strongly and independently associated with duration and severity of the disease. Additional associations between cortical GM atrophy and deep GM iron accumulation appear to exist in a region specific manner.

U2 - 10.1177/1352458514531085

DO - 10.1177/1352458514531085

M3 - Journal article

C2 - 24787429

SN - 1352-4585

VL - 20

SP - 1692

EP - 1698

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

IS - 13

ER -

Determinants of iron accumulation in deep grey matter of multiple sclerosis patients

Abstract

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