Detergents in the indoor environment - what is the evidence for an allergy promoting effect?: Known and postulated mechanisms

Lars K. Poulsen; S K Clausen; C Glue; A Millner; G D Nielsen; T Jinquan

Detergents in the indoor environment - what is the evidence for an allergy promoting effect? Known and postulated mechanisms

Lars K. Poulsen, S K Clausen, C Glue, A Millner, G D Nielsen, T Jinquan

11 Citations (Scopus)

Abstract

IgE-mediated allergic diseases, such as asthma and rhinitis seem to be increasing in industrialised societies. One possible explanation for this could be the increased use of more effective and aggressive detergents. The surfactants from these could interfere with the sensitisation process in which specific IgE is formed to ubiquitously occurring environmental allergens. Only sparse data exist in relation to surfactants and allergic sensitization. However, it can be speculated that the strong surfactant properties of some of ingredients used in modem detergents may interfere with some of the intricate cellular interactions taking place along the immunological pathways. These include formation of IL-4 and IL-5 producing T helper lymphocytes type 2 and the B-lymphocyte isotype switch, which leads to production of specific IgE. Candidates for experimental studies of such phenomena on the cellular level are proposed.

Original language	English
Journal	Toxicology
Volume	152
Issue number	1-3
Pages (from-to)	79-85
Number of pages	7
ISSN	0300-483X
Publication status	Published - 2 Nov 2000

Keywords

Air Pollution, Indoor
Animals
Cell Differentiation
Cytokines
Detergents
Humans
Hypersensitivity
Immunoglobulin Class Switching
Immunoglobulin E

Cite this

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title = "Detergents in the indoor environment - what is the evidence for an allergy promoting effect?: Known and postulated mechanisms",

abstract = "IgE-mediated allergic diseases, such as asthma and rhinitis seem to be increasing in industrialised societies. One possible explanation for this could be the increased use of more effective and aggressive detergents. The surfactants from these could interfere with the sensitisation process in which specific IgE is formed to ubiquitously occurring environmental allergens. Only sparse data exist in relation to surfactants and allergic sensitization. However, it can be speculated that the strong surfactant properties of some of ingredients used in modem detergents may interfere with some of the intricate cellular interactions taking place along the immunological pathways. These include formation of IL-4 and IL-5 producing T helper lymphocytes type 2 and the B-lymphocyte isotype switch, which leads to production of specific IgE. Candidates for experimental studies of such phenomena on the cellular level are proposed.",

keywords = "Air Pollution, Indoor, Animals, Cell Differentiation, Cytokines, Detergents, Humans, Hypersensitivity, Immunoglobulin Class Switching, Immunoglobulin E",

author = "Poulsen, {Lars K.} and Clausen, {S K} and C Glue and A Millner and Nielsen, {G D} and T Jinquan",

year = "2000",

month = nov,

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language = "English",

volume = "152",

pages = "79--85",

journal = "Toxicology",

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TY - JOUR

T1 - Detergents in the indoor environment - what is the evidence for an allergy promoting effect?

T2 - Known and postulated mechanisms

AU - Poulsen, Lars K.

AU - Clausen, S K

AU - Glue, C

AU - Millner, A

AU - Nielsen, G D

AU - Jinquan, T

PY - 2000/11/2

Y1 - 2000/11/2

N2 - IgE-mediated allergic diseases, such as asthma and rhinitis seem to be increasing in industrialised societies. One possible explanation for this could be the increased use of more effective and aggressive detergents. The surfactants from these could interfere with the sensitisation process in which specific IgE is formed to ubiquitously occurring environmental allergens. Only sparse data exist in relation to surfactants and allergic sensitization. However, it can be speculated that the strong surfactant properties of some of ingredients used in modem detergents may interfere with some of the intricate cellular interactions taking place along the immunological pathways. These include formation of IL-4 and IL-5 producing T helper lymphocytes type 2 and the B-lymphocyte isotype switch, which leads to production of specific IgE. Candidates for experimental studies of such phenomena on the cellular level are proposed.

AB - IgE-mediated allergic diseases, such as asthma and rhinitis seem to be increasing in industrialised societies. One possible explanation for this could be the increased use of more effective and aggressive detergents. The surfactants from these could interfere with the sensitisation process in which specific IgE is formed to ubiquitously occurring environmental allergens. Only sparse data exist in relation to surfactants and allergic sensitization. However, it can be speculated that the strong surfactant properties of some of ingredients used in modem detergents may interfere with some of the intricate cellular interactions taking place along the immunological pathways. These include formation of IL-4 and IL-5 producing T helper lymphocytes type 2 and the B-lymphocyte isotype switch, which leads to production of specific IgE. Candidates for experimental studies of such phenomena on the cellular level are proposed.

KW - Air Pollution, Indoor

KW - Animals

KW - Cell Differentiation

KW - Cytokines

KW - Detergents

KW - Humans

KW - Hypersensitivity

KW - Immunoglobulin Class Switching

KW - Immunoglobulin E

M3 - Journal article

C2 - 11090942

SN - 0300-483X

VL - 152

SP - 79

EP - 85

JO - Toxicology

JF - Toxicology

IS - 1-3

ER -

Detergents in the indoor environment - what is the evidence for an allergy promoting effect? Known and postulated mechanisms

Abstract

Keywords

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