Detecting the brachyspina mutation

Michel Georges; Wouter Coppieters; Carole Charlier; Jørgen Steen Agerholm; Merete Fredholm; Peter Karlskov-Mortensen

Detecting the brachyspina mutation

Michel Georges (Inventor), Wouter Coppieters (Inventor), Carole Charlier (Inventor), Jørgen Steen Agerholm (Inventor), Merete Fredholm (Inventor), Peter Karlskov-Mortensen (Inventor)

Abstract

This invention relates to methods for the detection of a bovine that is affected by or carrier of brachyspina. It is based on the identification of a 3.3 Kb deletion in the bovine FANCI gene that is shown to cause the brachyspina syndrome. The present invention provides methods and uses for determining whether a bovine is affected by or carrier of brachyspina by analyzing its genomic DNA or its RNA. The methods can be used to perform marker assisted selection or genomic selection for increased fertility in said bovine.

Original language	English
IPC	C12Q 1/68 (2006.01)
Patent number	WO 2012/155995 A1
Filing date	22/11/2012
Country/Territory	Denmark
Publication status	Published - 2012

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title = "Detecting the brachyspina mutation",

abstract = "This invention relates to methods for the detection of a bovine that is affected by or carrier of brachyspina. It is based on the identification of a 3.3 Kb deletion in the bovine FANCI gene that is shown to cause the brachyspina syndrome. The present invention provides methods and uses for determining whether a bovine is affected by or carrier of brachyspina by analyzing its genomic DNA or its RNA. The methods can be used to perform marker assisted selection or genomic selection for increased fertility in said bovine.",

author = "Michel Georges and Wouter Coppieters and Carole Charlier and Agerholm, {J{\o}rgen Steen} and Merete Fredholm and Peter Karlskov-Mortensen",

year = "2012",

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type = "Patent",

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T1 - Detecting the brachyspina mutation

AU - Georges, Michel

AU - Coppieters, Wouter

AU - Charlier, Carole

AU - Agerholm, Jørgen Steen

AU - Fredholm, Merete

AU - Karlskov-Mortensen, Peter

PY - 2012

Y1 - 2012

N2 - This invention relates to methods for the detection of a bovine that is affected by or carrier of brachyspina. It is based on the identification of a 3.3 Kb deletion in the bovine FANCI gene that is shown to cause the brachyspina syndrome. The present invention provides methods and uses for determining whether a bovine is affected by or carrier of brachyspina by analyzing its genomic DNA or its RNA. The methods can be used to perform marker assisted selection or genomic selection for increased fertility in said bovine.

AB - This invention relates to methods for the detection of a bovine that is affected by or carrier of brachyspina. It is based on the identification of a 3.3 Kb deletion in the bovine FANCI gene that is shown to cause the brachyspina syndrome. The present invention provides methods and uses for determining whether a bovine is affected by or carrier of brachyspina by analyzing its genomic DNA or its RNA. The methods can be used to perform marker assisted selection or genomic selection for increased fertility in said bovine.

M3 - Patent

M1 - WO 2012/155995 A1

Y2 - 2012/11/22

ER -