Abstract
Currently, most of the approved protein and peptide-based medicines are delivered via conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent dosing regimen is often necessary because of their short plasma half-lives, causing poor patient compliance (e.g. pain, abscess, etc.), side effects owing to typical peak-valley plasma concentration time profiles, and increased costs. Among many sustained-release formulations poly lactic-co-glycolic acid (PLGA)-based depot microparticle systems may represent one of the most promising approaches to provide protein and peptide drugs with a steady pharmacokinetic/pharmacodynamic profile maintained for a long period. However, the development of PLGA-based microparticle systems is still impeded by lack of easy, fast, effective manufacturing technologies. The aim of this paper is to review recent advances in spray drying, a one-step, continuous microencapsulation process, for manufacturing of PLGA-based depot microparticle systems with a focus on the recent efforts on understanding of the role of nozzle design in the microencapsulation of proteins/peptides, and the effect of critical solvent properties and process parameters on the critical quality attributes of the spray-dried microparticles.
| Original language | English |
|---|---|
| Journal | International Journal of Pharmaceutics |
| Volume | 498 |
| Issue number | 1-2 |
| Pages (from-to) | 82-95 |
| Number of pages | 14 |
| ISSN | 0378-5173 |
| DOIs | |
| Publication status | Published - 10 Feb 2016 |
Keywords
- Animals
- Biopharmaceutics
- Chemistry, Pharmaceutical
- Delayed-Action Preparations
- Drug Delivery Systems
- Drug Design
- Humans
- Lactic Acid
- Polyglycolic Acid
- Journal Article
- Research Support, Non-U.S. Gov't
- Review