TY - JOUR
T1 - Design and rationale of the HITTS randomized controlled trial
T2 - Effect of High-intensity Interval Training in de novo Heart Transplant Recipients in Scandinavia
AU - Nytrøen, Kari
AU - Yardley, Marianne
AU - Rolid, Katrine
AU - Bjørkelund, Elisabeth
AU - Karason, Kristjan
AU - Wigh, Julia Philip
AU - Dall, Christian Have
AU - Arora, Satish
AU - Aakhus, Svend
AU - Lunde, Ketil
AU - Solberg, Ole Geir
AU - Gustafsson, Finn
AU - Prescott, Eva Irene Bossano
AU - Gullestad, Lars
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - There is no consensus on how, when, and at what intensity exercise should be performed and organized after heart transplantation (HTx). Most rehabilitation programs are conducted in HTx centers, which might be impractical and costly. We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in maintenance HTx recipients, but there are no studies among de novo patients, and whether HIT is feasible and superior to moderate training in HTx recipients is unclear. A total of 120 clinically stable HTx recipients older than 18 years will be recruited from 3 Scandinavian HTx centers. Participants are randomized to HIT or moderate training, shortly after surgery. All exercises are supervised in the patients' local communities. Testing at baseline and follow-up includes the following: VO2peak (primary end point), muscle strength, body composition, quality of life, myocardial performance, endothelial function, biomarkers, and progression of cardiac allograft vasculopathy. A subgroup (n = 90) will also be tested at 3-year follow-up to assess long-term effects of exercise. So far, the HIT intervention is well tolerated, without any serious adverse events. We aim to test whether decentralized HIT is feasible, safe, and superior to moderate training, and whether it will lead to significant improvement in exercise capacity and less long-term complications.
AB - There is no consensus on how, when, and at what intensity exercise should be performed and organized after heart transplantation (HTx). Most rehabilitation programs are conducted in HTx centers, which might be impractical and costly. We have recently shown that high-intensity interval training (HIT) is safe, well tolerated, and efficacious in maintenance HTx recipients, but there are no studies among de novo patients, and whether HIT is feasible and superior to moderate training in HTx recipients is unclear. A total of 120 clinically stable HTx recipients older than 18 years will be recruited from 3 Scandinavian HTx centers. Participants are randomized to HIT or moderate training, shortly after surgery. All exercises are supervised in the patients' local communities. Testing at baseline and follow-up includes the following: VO2peak (primary end point), muscle strength, body composition, quality of life, myocardial performance, endothelial function, biomarkers, and progression of cardiac allograft vasculopathy. A subgroup (n = 90) will also be tested at 3-year follow-up to assess long-term effects of exercise. So far, the HIT intervention is well tolerated, without any serious adverse events. We aim to test whether decentralized HIT is feasible, safe, and superior to moderate training, and whether it will lead to significant improvement in exercise capacity and less long-term complications.
KW - Exercise Therapy
KW - Heart Transplantation
KW - Humans
KW - Patient Education as Topic
KW - Postoperative Care
KW - Randomized Controlled Trials as Topic
KW - Research Design
KW - Scandinavian and Nordic Countries
KW - Transplant Recipients
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.ahj.2015.10.011
DO - 10.1016/j.ahj.2015.10.011
M3 - Journal article
C2 - 26856221
SN - 0002-8703
VL - 172
SP - 96
EP - 105
JO - American Heart Journal
JF - American Heart Journal
ER -