Depressive symptoms in first-episode psychosis: a 10-year follow-up study

Nasrettin Sönmez; Jan Ivar Røssberg; Julie Evensen; Helene Eidsmo Barder; Ulrik Haahr; Wenche Ten Velden Hegelstad; Inge Joa; Jan Olav Johannessen; Hans Langeveld; Tor Ketil Larsen; Ingrid Melle; Stein Opjordsmoen; Bjørn Rishovd Rund; Erik Simonsen; Per Vaglum; Thomas McGlashan; Svein Friis

doi:10.1111/eip.12163

Depressive symptoms in first-episode psychosis: a 10-year follow-up study

Nasrettin Sönmez, Jan Ivar Røssberg, Julie Evensen, Helene Eidsmo Barder, Ulrik Haahr, Wenche Ten Velden Hegelstad, Inge Joa, Jan Olav Johannessen, Hans Langeveld, Tor Ketil Larsen, Ingrid Melle, Stein Opjordsmoen, Bjørn Rishovd Rund, Erik Simonsen, Per Vaglum, Thomas McGlashan, Svein Friis

Department of Clinical Medicine

27 Citations (Scopus)

Abstract

AIMS: The present study examined if any patient characteristics at baseline predicted depressive symptoms at 10 years and whether patients prone to depressive symptoms in the first year of treatment had a different prognosis in the following years.

METHOD: A total of 299 first-episode psychosis (FEP) patients with schizophrenia spectrum disorders were assessed for depressive symptoms with PANSS depression item (g6) at baseline, and 1, 2, 5 and 10 years of follow up. At 10 years, depressive symptoms were also assessed with Calgary Depression Scale for Schizophrenia (CDSS). A PANSS g6 ≥ 4 and CDSS score ≥ 6 were used as a cut-off score for depression.

RESULTS: A total of 122 (41%) patients were scored as depressed at baseline, 75 (28%) at 1 year, 50 (20%) at 2 years, 33 (16%) at 5 years, and 35 (19%) at 10 years of follow up. Poor childhood social functioning and alcohol use at baseline predicted depression at 10 years of follow up. Thirty-eight patients were depressed at both baseline and 1 year follow up. This group had poorer symptomatic and functional outcome in the follow-up period compared to a group of patients with no depression in the first year of treatment.

CONCLUSION: Depressive symptoms are frequent among FEP patients at baseline but decrease after treatment because their general symptoms have been initiated. Patients with poor social functioning in childhood and alcohol use at baseline are more prone to have depressive symptoms at 10 years of follow up. Patients struggling with depressive symptoms in the first year of treatment should be identified as having poorer long-term prognosis.

Original language	English
Journal	Early Intervention in Psychiatry
Volume	10
Issue number	3
Pages (from-to)	227–233
ISSN	1751-7885
DOIs	https://doi.org/10.1111/eip.12163
Publication status	Published - 1 Jun 2016

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Sönmez, N., Røssberg, J. I., Evensen, J., Barder, H. E., Haahr, U., Ten Velden Hegelstad, W., Joa, I., Johannessen, J. O., Langeveld, H., Larsen, T. K., Melle, I., Opjordsmoen, S., Rund, B. R., Simonsen, E., Vaglum, P., McGlashan, T., & Friis, S. (2016). Depressive symptoms in first-episode psychosis: a 10-year follow-up study. Early Intervention in Psychiatry, 10(3), 227–233. https://doi.org/10.1111/eip.12163

Sönmez, N, Røssberg, JI, Evensen, J, Barder, HE, Haahr, U, Ten Velden Hegelstad, W, Joa, I, Johannessen, JO, Langeveld, H, Larsen, TK, Melle, I, Opjordsmoen, S, Rund, BR, Simonsen, E, Vaglum, P, McGlashan, T & Friis, S 2016, 'Depressive symptoms in first-episode psychosis: a 10-year follow-up study', Early Intervention in Psychiatry, vol. 10, no. 3, pp. 227–233. https://doi.org/10.1111/eip.12163

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title = "Depressive symptoms in first-episode psychosis: a 10-year follow-up study",

abstract = "AIMS: The present study examined if any patient characteristics at baseline predicted depressive symptoms at 10 years and whether patients prone to depressive symptoms in the first year of treatment had a different prognosis in the following years.METHOD: A total of 299 first-episode psychosis (FEP) patients with schizophrenia spectrum disorders were assessed for depressive symptoms with PANSS depression item (g6) at baseline, and 1, 2, 5 and 10 years of follow up. At 10 years, depressive symptoms were also assessed with Calgary Depression Scale for Schizophrenia (CDSS). A PANSS g6 ≥ 4 and CDSS score ≥ 6 were used as a cut-off score for depression.RESULTS: A total of 122 (41%) patients were scored as depressed at baseline, 75 (28%) at 1 year, 50 (20%) at 2 years, 33 (16%) at 5 years, and 35 (19%) at 10 years of follow up. Poor childhood social functioning and alcohol use at baseline predicted depression at 10 years of follow up. Thirty-eight patients were depressed at both baseline and 1 year follow up. This group had poorer symptomatic and functional outcome in the follow-up period compared to a group of patients with no depression in the first year of treatment.CONCLUSION: Depressive symptoms are frequent among FEP patients at baseline but decrease after treatment because their general symptoms have been initiated. Patients with poor social functioning in childhood and alcohol use at baseline are more prone to have depressive symptoms at 10 years of follow up. Patients struggling with depressive symptoms in the first year of treatment should be identified as having poorer long-term prognosis.",

author = "Nasrettin S{\"o}nmez and R{\o}ssberg, {Jan Ivar} and Julie Evensen and Barder, {Helene Eidsmo} and Ulrik Haahr and {Ten Velden Hegelstad}, Wenche and Inge Joa and Johannessen, {Jan Olav} and Hans Langeveld and Larsen, {Tor Ketil} and Ingrid Melle and Stein Opjordsmoen and Rund, {Bj{\o}rn Rishovd} and Erik Simonsen and Per Vaglum and Thomas McGlashan and Svein Friis",

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doi = "10.1111/eip.12163",

language = "English",

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T1 - Depressive symptoms in first-episode psychosis

T2 - a 10-year follow-up study

AU - Sönmez, Nasrettin

AU - Røssberg, Jan Ivar

AU - Evensen, Julie

AU - Barder, Helene Eidsmo

AU - Haahr, Ulrik

AU - Ten Velden Hegelstad, Wenche

AU - Joa, Inge

AU - Johannessen, Jan Olav

AU - Langeveld, Hans

AU - Larsen, Tor Ketil

AU - Melle, Ingrid

AU - Opjordsmoen, Stein

AU - Rund, Bjørn Rishovd

AU - Simonsen, Erik

AU - Vaglum, Per

AU - McGlashan, Thomas

AU - Friis, Svein

PY - 2016/6/1

Y1 - 2016/6/1

N2 - AIMS: The present study examined if any patient characteristics at baseline predicted depressive symptoms at 10 years and whether patients prone to depressive symptoms in the first year of treatment had a different prognosis in the following years.METHOD: A total of 299 first-episode psychosis (FEP) patients with schizophrenia spectrum disorders were assessed for depressive symptoms with PANSS depression item (g6) at baseline, and 1, 2, 5 and 10 years of follow up. At 10 years, depressive symptoms were also assessed with Calgary Depression Scale for Schizophrenia (CDSS). A PANSS g6 ≥ 4 and CDSS score ≥ 6 were used as a cut-off score for depression.RESULTS: A total of 122 (41%) patients were scored as depressed at baseline, 75 (28%) at 1 year, 50 (20%) at 2 years, 33 (16%) at 5 years, and 35 (19%) at 10 years of follow up. Poor childhood social functioning and alcohol use at baseline predicted depression at 10 years of follow up. Thirty-eight patients were depressed at both baseline and 1 year follow up. This group had poorer symptomatic and functional outcome in the follow-up period compared to a group of patients with no depression in the first year of treatment.CONCLUSION: Depressive symptoms are frequent among FEP patients at baseline but decrease after treatment because their general symptoms have been initiated. Patients with poor social functioning in childhood and alcohol use at baseline are more prone to have depressive symptoms at 10 years of follow up. Patients struggling with depressive symptoms in the first year of treatment should be identified as having poorer long-term prognosis.

AB - AIMS: The present study examined if any patient characteristics at baseline predicted depressive symptoms at 10 years and whether patients prone to depressive symptoms in the first year of treatment had a different prognosis in the following years.METHOD: A total of 299 first-episode psychosis (FEP) patients with schizophrenia spectrum disorders were assessed for depressive symptoms with PANSS depression item (g6) at baseline, and 1, 2, 5 and 10 years of follow up. At 10 years, depressive symptoms were also assessed with Calgary Depression Scale for Schizophrenia (CDSS). A PANSS g6 ≥ 4 and CDSS score ≥ 6 were used as a cut-off score for depression.RESULTS: A total of 122 (41%) patients were scored as depressed at baseline, 75 (28%) at 1 year, 50 (20%) at 2 years, 33 (16%) at 5 years, and 35 (19%) at 10 years of follow up. Poor childhood social functioning and alcohol use at baseline predicted depression at 10 years of follow up. Thirty-eight patients were depressed at both baseline and 1 year follow up. This group had poorer symptomatic and functional outcome in the follow-up period compared to a group of patients with no depression in the first year of treatment.CONCLUSION: Depressive symptoms are frequent among FEP patients at baseline but decrease after treatment because their general symptoms have been initiated. Patients with poor social functioning in childhood and alcohol use at baseline are more prone to have depressive symptoms at 10 years of follow up. Patients struggling with depressive symptoms in the first year of treatment should be identified as having poorer long-term prognosis.

U2 - 10.1111/eip.12163

DO - 10.1111/eip.12163

M3 - Journal article

C2 - 24956976

SN - 1751-7885

VL - 10

SP - 227

EP - 233

JO - Early Intervention in Psychiatry

JF - Early Intervention in Psychiatry

IS - 3

ER -

Depressive symptoms in first-episode psychosis: a 10-year follow-up study

Abstract

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