Abstract
Pancreatic tissue from 16 post mortem kidney donors have been examined for the content of pepsinogens. A zymogen with electrophoretic mobility, isoelectric point and molecular weight equal to that of pepsinogen C of gastric origin was found in all specimens. A comparison between pepsinogen C extracted from pancreatic tissue and gastric mucosa demonstrated immunological identity. Quantitative measurements with a radioimmunoassay showed pepsinogen C concentrations in pancreatic tissue three to 80 times higher than those of blood serum. Immunohistochemical staining gave positive reaction for pepsinogen C only in the alpha cells of the pancreatic islets.
| Original language | English |
|---|---|
| Journal | Gut |
| Volume | 28 |
| Issue number | 10 |
| Pages (from-to) | 1208-14 |
| Number of pages | 7 |
| ISSN | 0017-5749 |
| Publication status | Published - Oct 1987 |
Keywords
- Electrophoresis, Agar Gel
- Electrophoresis, Polyacrylamide Gel
- Gastric Mucosa
- Humans
- Immunoenzyme Techniques
- Islets of Langerhans
- Isoelectric Focusing
- Pepsinogens