Delayed early proprioceptive information processing in schizophrenia

TY - JOUR

T1 - Delayed early proprioceptive information processing in schizophrenia

AU - Arnfred, Sidse M

AU - Hemmingsen, RP

AU - Parnas, Josef

AU - Hemmingsen, Ralf

PY - 2006/12/1

Y1 - 2006/12/1

N2 - It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the "deficiency of corollary discharge" model of schizophrenia but not within the "filtering" theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.

AB - It was first suggested that disordered proprioception was a core feature of schizophrenia by Sandor Rado in 1953. Using a recently designed proprioceptive event-related potential paradigm based on a change of load, we studied 12 unmedicated male out-patients with schizophrenia and 24 controls. In the patients, the early contralateral parietal activity was delayed and later central activity had increased amplitude, but gating was unaffected. The results could be understood within the "deficiency of corollary discharge" model of schizophrenia but not within the "filtering" theory. Further studies, including psychiatric controls, are necessary to verify the specificity of the abnormality.

U2 - 10.1192/bjp.bp.105.017087

DO - 10.1192/bjp.bp.105.017087

M3 - Journal article

C2 - 17139042

SN - 0960-5371

VL - 189

SP - 558

EP - 559

JO - The Journal of mental science

JF - The Journal of mental science

ER -