Decreased plasma chemerin levels in women with gestational diabetes mellitus

TY - JOUR

T1 - Decreased plasma chemerin levels in women with gestational diabetes mellitus

AU - Hare, K J

AU - Bonde, L

AU - Svare, J A

AU - Randeva, H S

AU - Asmar, M

AU - Larsen, S

AU - Vilsbøll, T

AU - Knop, F K

N1 - © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.

PY - 2014/8

Y1 - 2014/8

N2 - Aims: To evaluate fasting and post-prandial serum chemerin levels in pregnant women with and without gestational diabetes, and again following delivery when normal glucose homeostasis is re-established. Methods: Chemerin levels were measured in serum from nine women with gestational diabetes, and from eight age- and BMI-matched pregnant women with normal glucose tolerance during two meal tests: in the third trimester and 3-4 months post partum. All women with gestational diabetes re-established normal glucose tolerance after delivery. Results: Meal intake did not affect serum chemerin levels. The group with gestational diabetes had lower mean serum chemerin levels during the third trimester compared with the group with normal glucose tolerance (28 ± 1.3 vs. 88 ± 3.5 ng/ml, P < 0.0001). In the group with normal glucose tolerance, mean serum chemerin levels decreased significantly post partum to 57 ± 2.8 ng/ml (P = 0.0001), but remained significantly (P = 0.0003) higher than post-partum levels in the group with gestational diabetes (31 ± 1.9 ng/ml), which did not differ significantly from third trimester levels (P = 0.31). Conclusions: Normal pregnancy is associated with increased circulating chemerin levels, which may act to reduce pregnancy-induced insulin resistance and prevent glucose intolerance. Women with gestational diabetes, however, have severely reduced chemerin levels that remain low after delivery, which may contribute to the insulin resistance, glucose intolerance and high Type 2 diabetes risk associated with gestational diabetes.

AB - Aims: To evaluate fasting and post-prandial serum chemerin levels in pregnant women with and without gestational diabetes, and again following delivery when normal glucose homeostasis is re-established. Methods: Chemerin levels were measured in serum from nine women with gestational diabetes, and from eight age- and BMI-matched pregnant women with normal glucose tolerance during two meal tests: in the third trimester and 3-4 months post partum. All women with gestational diabetes re-established normal glucose tolerance after delivery. Results: Meal intake did not affect serum chemerin levels. The group with gestational diabetes had lower mean serum chemerin levels during the third trimester compared with the group with normal glucose tolerance (28 ± 1.3 vs. 88 ± 3.5 ng/ml, P < 0.0001). In the group with normal glucose tolerance, mean serum chemerin levels decreased significantly post partum to 57 ± 2.8 ng/ml (P = 0.0001), but remained significantly (P = 0.0003) higher than post-partum levels in the group with gestational diabetes (31 ± 1.9 ng/ml), which did not differ significantly from third trimester levels (P = 0.31). Conclusions: Normal pregnancy is associated with increased circulating chemerin levels, which may act to reduce pregnancy-induced insulin resistance and prevent glucose intolerance. Women with gestational diabetes, however, have severely reduced chemerin levels that remain low after delivery, which may contribute to the insulin resistance, glucose intolerance and high Type 2 diabetes risk associated with gestational diabetes.

KW - Adult

KW - Chemokines

KW - Cohort Studies

KW - Diabetes, Gestational

KW - Down-Regulation

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Insulin Resistance

KW - Postpartum Period

KW - Postprandial Period

KW - Pregnancy

KW - Pregnancy Trimester, Third

KW - Up-Regulation

U2 - 10.1111/dme.12436

DO - 10.1111/dme.12436

M3 - Journal article

C2 - 24628007

SN - 0742-3071

VL - 31

SP - 936

EP - 940

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 8

ER -