Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

Kasper Aanæs; Lars Fledelius Rickelt; Helle Krogh Johansen; Christian von Buchwald; Tacjana Pressler; Niels Høiby; Peter Østrup Jensen

doi:10.1016/j.jcf.2010.12.002

Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

Kasper Aanæs, Lars Fledelius Rickelt, Helle Krogh Johansen, Christian von Buchwald, Tacjana Pressler, Niels Høiby, Peter Østrup Jensen

36 Citations (Scopus)

Abstract

Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses. Methods: The oxygen tension (pO₂) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients. Results: The CF patients had a significant lower pO₂ on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci. Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.

Original language	English
Journal	Journal of Cystic Fibrosis
Volume	10
Issue number	2
Pages (from-to)	114-120
Number of pages	7
ISSN	1569-1993
DOIs	https://doi.org/10.1016/j.jcf.2010.12.002
Publication status	Published - Mar 2011

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title = "Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis",

abstract = "Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses. Methods: The oxygen tension (pO2) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients. Results: The CF patients had a significant lower pO2 on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci. Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.",

author = "Kasper Aan{\ae}s and Rickelt, {Lars Fledelius} and Johansen, {Helle Krogh} and {von Buchwald}, Christian and Tacjana Pressler and Niels H{\o}iby and Jensen, {Peter {\O}strup}",

year = "2011",

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doi = "10.1016/j.jcf.2010.12.002",

language = "English",

volume = "10",

pages = "114--120",

journal = "Journal of Cystic Fibrosis",

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TY - JOUR

T1 - Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

AU - Aanæs, Kasper

AU - Rickelt, Lars Fledelius

AU - Johansen, Helle Krogh

AU - von Buchwald, Christian

AU - Pressler, Tacjana

AU - Høiby, Niels

AU - Jensen, Peter Østrup

PY - 2011/3

Y1 - 2011/3

N2 - Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses. Methods: The oxygen tension (pO2) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients. Results: The CF patients had a significant lower pO2 on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci. Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.

AB - Background: Pseudomonas aeruginosa in the sinuses plays a role in the lungs in cystic fibrosis (CF) patients, but little is known about the sinus environment where the bacteria adapt. Anoxic areas are found in the lower respiratory airways but it is unknown if the same conditions exist in the sinuses. Methods: The oxygen tension (pO2) was measured, using a novel in vivo method, in the maxillary sinus in a group of 20 CF patients. Results: The CF patients had a significant lower pO2 on the mucosa but not in the sinus lumen as compared with a control group of non-CF patients. Anoxic conditions were found in 7/39 (18%) of the sinuses from where we cultured P. aeruginosa, Stenotrophomonas maltophilia and/or coagulase negative staphylococci. Conclusion: These findings support our hypothesis that P. aeruginosa can adapt or acclimate to the environment in the lungs, during growth in anoxic parts of the paranasal sinuses.

U2 - 10.1016/j.jcf.2010.12.002

DO - 10.1016/j.jcf.2010.12.002

M3 - Journal article

C2 - 21208831

SN - 1569-1993

VL - 10

SP - 114

EP - 120

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 2

ER -

Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis

Abstract

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