Dangerous R loops form in the absence of H3K9 methylation

Anna Elisabetta Salcini

doi:10.1038/ng.3705

Dangerous R loops form in the absence of H3K9 methylation

Abstract

Methylation of histone H3 on lysine 9 (H3K9) is a hallmark of transcriptionally inactive heterochromatin that is deregulated in pathological conditions. A new study shows that complete loss of H3K9 methylation in Caenorhabditis elegans leads to derepression of repetitive elements and formation of DNA:RNA hybrids (R loops), resulting in increased rates of repeat-specific mutation.

Original language	English
Journal	Nature Genetics
Volume	48
Issue number	11
Pages (from-to)	1299-1300
Number of pages	2
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.3705
Publication status	Published - 1 Nov 2016

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abstract = "Methylation of histone H3 on lysine 9 (H3K9) is a hallmark of transcriptionally inactive heterochromatin that is deregulated in pathological conditions. A new study shows that complete loss of H3K9 methylation in Caenorhabditis elegans leads to derepression of repetitive elements and formation of DNA:RNA hybrids (R loops), resulting in increased rates of repeat-specific mutation.",

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AB - Methylation of histone H3 on lysine 9 (H3K9) is a hallmark of transcriptionally inactive heterochromatin that is deregulated in pathological conditions. A new study shows that complete loss of H3K9 methylation in Caenorhabditis elegans leads to derepression of repetitive elements and formation of DNA:RNA hybrids (R loops), resulting in increased rates of repeat-specific mutation.

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JO - Nature Genetics

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Dangerous R loops form in the absence of H3K9 methylation

Abstract

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