Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania

Nyagosya  Range; George PrayGod; Daniel Faurholt-Jepsen; Kidola Jeremiah; Maria Faurholt-Jepsen; Martine G. Aabye; Lotte  Jensen; Andreas V. Jensen; Harleen M.S. Grewal; Pascal Magnussen; John Changalucha; Aase Bengaard Andersen; Henrik Friis

Abstract

Undernutrition is common among tuberculosis (TB) patients. The objective of this study was to assess the effect of multi-micronutrient supplementation during TB treatment on weight, body composition, and handgrip strength. A total of 865 patientswith smear-positive (PTB+) or -negative (PTB-) pulmonary TBwere randomly allocated to receive a daily biscuitwith or without multi-micronutrients for 60 d during the intensive phase of TB treatment.Weight, arm fat area, arm muscle area, and handgrip strength were assessed at baseline and after 2 and 5 mo. At 2 mo, the multi-micronutrient supplementation led to a higher handgrip gain (1.22 kg; 95% CI = 0.50, 1.94; P = 0.001) but had no effects on other outcomes. The effects of multimicronutrient supplementation were modified by HIV infection (P-interaction = 0.002). Among HIV- patients, multimicronutrient supplementation increased weight gain by 590 g (95% CI =240, 1210; P = 0.07) and handgrip strength by 1.6 kg (95%CI = 0.78, 2.47; P < 0.001), whereas among HIV+ patients, it reduced weight gain by 1440 g (95%CI = 290, 2590; P = 0.002) and had no effect on handgrip strength (0.07 kg; 95% CI =21.30, 1.46; P = 0.91). The reducedweight gain among HIV+ patients receiving multi-micronutrient supplementation seemed to be explained by a higher proportion of patients reporting fever. At 5mo, the effects on weight were sustained, whereas there was no effect on handgrip strength. In conclusion, multimicronutrient supplementation given as a biscuit is beneficial among HIV2 PTB patients and may be recommended to TB programs. More research is needed to develop an effective supplement for HIV+ PTB patients.

Original language	English
Publication date	1 Apr 2011
Number of pages	1
Publication status	Published - 1 Apr 2011
Event	The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum - Arusha, Tanzania, United Republic of Duration: 5 Apr 2011 → 7 Apr 2011

Conference

Conference	The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum
Country/Territory	Tanzania, United Republic of
City	Arusha
Period	05/04/2011 → 07/04/2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, TanzaniaFinal published version, 356 KB

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Range, N., PrayGod, G., Faurholt-Jepsen, D., Jeremiah, K., Faurholt-Jepsen, M., Aabye, M. G., Jensen, L., Jensen, A. V., Grewal, H. M. S., Magnussen, P., Changalucha, J., Andersen, A. B., & Friis, H. (2011). Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania. Abstract from The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum , Arusha, Tanzania, United Republic of.

Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania. / Range, Nyagosya ; PrayGod, George; Faurholt-Jepsen, Daniel et al.

2011. Abstract from The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum , Arusha, Tanzania, United Republic of.

Research output: Contribution to conference › Conference abstract for conference › Research

Range, N, PrayGod, G, Faurholt-Jepsen, D, Jeremiah, K, Faurholt-Jepsen, M, Aabye, MG, Jensen, L, Jensen, AV, Grewal, HMS, Magnussen, P, Changalucha, J, Andersen, AB & Friis, H 2011, 'Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania', The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum , Arusha, Tanzania, United Republic of, 05/04/2011 - 07/04/2011.

Range N, PrayGod G, Faurholt-Jepsen D, Jeremiah K, Faurholt-Jepsen M, Aabye MG et al.. Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania. 2011. Abstract from The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum , Arusha, Tanzania, United Republic of.

Range, Nyagosya ; PrayGod, George ; Faurholt-Jepsen, Daniel et al. / Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania. Abstract from The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum , Arusha, Tanzania, United Republic of.1 p.

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title = "Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania",

abstract = "Undernutrition is common among tuberculosis (TB) patients. The objective of this study was to assess the effect of multi-micronutrient supplementation during TB treatment on weight, body composition, and handgrip strength. A total of 865 patientswith smear-positive (PTB+) or -negative (PTB-) pulmonary TBwere randomly allocated to receive a daily biscuitwith or without multi-micronutrients for 60 d during the intensive phase of TB treatment.Weight, arm fat area, arm muscle area, and handgrip strength were assessed at baseline and after 2 and 5 mo. At 2 mo, the multi-micronutrient supplementation led to a higher handgrip gain (1.22 kg; 95% CI = 0.50, 1.94; P = 0.001) but had no effects on other outcomes. The effects of multimicronutrient supplementation were modified by HIV infection (P-interaction = 0.002). Among HIV- patients, multimicronutrient supplementation increased weight gain by 590 g (95% CI =240, 1210; P = 0.07) and handgrip strength by 1.6 kg (95%CI = 0.78, 2.47; P < 0.001), whereas among HIV+ patients, it reduced weight gain by 1440 g (95%CI = 290, 2590; P = 0.002) and had no effect on handgrip strength (0.07 kg; 95% CI =21.30, 1.46; P = 0.91). The reducedweight gain among HIV+ patients receiving multi-micronutrient supplementation seemed to be explained by a higher proportion of patients reporting fever. At 5mo, the effects on weight were sustained, whereas there was no effect on handgrip strength. In conclusion, multimicronutrient supplementation given as a biscuit is beneficial among HIV2 PTB patients and may be recommended to TB programs. More research is needed to develop an effective supplement for HIV+ PTB patients.",

author = "Nyagosya Range and George PrayGod and Daniel Faurholt-Jepsen and Kidola Jeremiah and Maria Faurholt-Jepsen and Aabye, {Martine G.} and Lotte Jensen and Jensen, {Andreas V.} and Grewal, {Harleen M.S.} and Pascal Magnussen and John Changalucha and Andersen, {Aase Bengaard} and Henrik Friis",

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T1 - Daily multi-micronutrient supplementation during tuberculosis treatment increases weight and grip strength among HIV uninfected but not HIV infected patients in Mwanza, Tanzania

AU - Range, Nyagosya

AU - PrayGod, George

AU - Faurholt-Jepsen, Daniel

AU - Jeremiah, Kidola

AU - Faurholt-Jepsen, Maria

AU - Aabye, Martine G.

AU - Jensen, Lotte

AU - Jensen, Andreas V.

AU - Grewal, Harleen M.S.

AU - Magnussen, Pascal

AU - Changalucha, John

AU - Andersen, Aase Bengaard

AU - Friis, Henrik

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Undernutrition is common among tuberculosis (TB) patients. The objective of this study was to assess the effect of multi-micronutrient supplementation during TB treatment on weight, body composition, and handgrip strength. A total of 865 patientswith smear-positive (PTB+) or -negative (PTB-) pulmonary TBwere randomly allocated to receive a daily biscuitwith or without multi-micronutrients for 60 d during the intensive phase of TB treatment.Weight, arm fat area, arm muscle area, and handgrip strength were assessed at baseline and after 2 and 5 mo. At 2 mo, the multi-micronutrient supplementation led to a higher handgrip gain (1.22 kg; 95% CI = 0.50, 1.94; P = 0.001) but had no effects on other outcomes. The effects of multimicronutrient supplementation were modified by HIV infection (P-interaction = 0.002). Among HIV- patients, multimicronutrient supplementation increased weight gain by 590 g (95% CI =240, 1210; P = 0.07) and handgrip strength by 1.6 kg (95%CI = 0.78, 2.47; P < 0.001), whereas among HIV+ patients, it reduced weight gain by 1440 g (95%CI = 290, 2590; P = 0.002) and had no effect on handgrip strength (0.07 kg; 95% CI =21.30, 1.46; P = 0.91). The reducedweight gain among HIV+ patients receiving multi-micronutrient supplementation seemed to be explained by a higher proportion of patients reporting fever. At 5mo, the effects on weight were sustained, whereas there was no effect on handgrip strength. In conclusion, multimicronutrient supplementation given as a biscuit is beneficial among HIV2 PTB patients and may be recommended to TB programs. More research is needed to develop an effective supplement for HIV+ PTB patients.

AB - Undernutrition is common among tuberculosis (TB) patients. The objective of this study was to assess the effect of multi-micronutrient supplementation during TB treatment on weight, body composition, and handgrip strength. A total of 865 patientswith smear-positive (PTB+) or -negative (PTB-) pulmonary TBwere randomly allocated to receive a daily biscuitwith or without multi-micronutrients for 60 d during the intensive phase of TB treatment.Weight, arm fat area, arm muscle area, and handgrip strength were assessed at baseline and after 2 and 5 mo. At 2 mo, the multi-micronutrient supplementation led to a higher handgrip gain (1.22 kg; 95% CI = 0.50, 1.94; P = 0.001) but had no effects on other outcomes. The effects of multimicronutrient supplementation were modified by HIV infection (P-interaction = 0.002). Among HIV- patients, multimicronutrient supplementation increased weight gain by 590 g (95% CI =240, 1210; P = 0.07) and handgrip strength by 1.6 kg (95%CI = 0.78, 2.47; P < 0.001), whereas among HIV+ patients, it reduced weight gain by 1440 g (95%CI = 290, 2590; P = 0.002) and had no effect on handgrip strength (0.07 kg; 95% CI =21.30, 1.46; P = 0.91). The reducedweight gain among HIV+ patients receiving multi-micronutrient supplementation seemed to be explained by a higher proportion of patients reporting fever. At 5mo, the effects on weight were sustained, whereas there was no effect on handgrip strength. In conclusion, multimicronutrient supplementation given as a biscuit is beneficial among HIV2 PTB patients and may be recommended to TB programs. More research is needed to develop an effective supplement for HIV+ PTB patients.

M3 - Conference abstract for conference

T2 - The 25th Annual Joint Scientific Conference and 10th Anniversary of the Tanzania National Health Research Forum

Y2 - 5 April 2011 through 7 April 2011

ER -