Cytochromes P450 for terpene functionalisation and metabolic engineering

Irini Pateraki, Allison Maree Heskes, Björn Robert Hamberger

77 Citations (Scopus)

Abstract

Plants have evolved the capacity to produce a striking array of specialised metabolites. Terpenoids are the oldest and most diverse class of such compounds and have attracted interest for industrial and pharmaceutical applications. The development of biotechnological alternatives for their production is the focus of intense research. Photosynthetic systems provide new strategies for autotrophic metabolic engineering. Focusing on cytochromes P450, involved in the functionalisation of the core terpene molecules, this review highlights the latest approaches in this field and looks towards recent discoveries that have the potential to shape the future of terpenoid bioengineering.

Original languageEnglish
Title of host publicationBiotechnology of Isoprenoids
Number of pages33
PublisherSpringer
Publication date2015
Pages107-139
ISBN (Print)978-3-319-20106-1
ISBN (Electronic)978-3-319-20107-8
DOIs
Publication statusPublished - 2015
SeriesAdvances in Biochemical Engineering. Biotechnology
Volume148
ISSN0724-6145

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