Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments

TY - JOUR

T1 - Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments

AU - Gauthier, Nicholas Paul

AU - Larsen, Malene Erup

AU - Wernersson, Rasmus

AU - de Lichtenberg, Ulrik

AU - Jensen, Lars Juhl

AU - Brunak, Søren

AU - Jensen, Thomas Skøt

PY - 2008

Y1 - 2008

N2 - The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.

AB - The past decade has seen the publication of a large number of cell-cycle microarray studies and many more are in the pipeline. However, data from these experiments are not easy to access, combine and evaluate. We have developed a centralized database with an easy-to-use interface, Cyclebase.org, for viewing and downloading these data. The user interface facilitates searches for genes of interest as well as downloads of genome-wide results. Individual genes are displayed with graphs of expression profiles throughout the cell cycle from all available experiments. These expression profiles are normalized to a common timescale to enable inspection of the combined experimental evidence. Furthermore, state-of-the-art computational analyses provide key information on both individual experiments and combined datasets such as whether or not a gene is periodically expressed and, if so, the time of peak expression. Cyclebase is available at http://www.cyclebase.org.

U2 - 10.1093/nar/gkm729

DO - 10.1093/nar/gkm729

M3 - Journal article

C2 - 17940094

SN - 0305-1048

VL - 36

SP - D854-9

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - Database issue

ER -