Cyanotic congenital heart disease and atherosclerosis

Julie Bjerre Tarp; Annette Schophuus Jensen; Thomas Engstrøm; Niels-Henrik Holstein-Rathlou; Lars Søndergaard

doi:10.1136/heartjnl-2016-311012

Cyanotic congenital heart disease and atherosclerosis

Julie Bjerre Tarp, Annette Schophuus Jensen, Thomas Engstrøm, Niels-Henrik Holstein-Rathlou, Lars Søndergaard

17 Citations (Scopus)

Abstract

Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.

Original language	English
Journal	Heart
Volume	103
Pages (from-to)	897-900
Number of pages	4
ISSN	1355-6037
DOIs	https://doi.org/10.1136/heartjnl-2016-311012
Publication status	Published - 1 Jun 2017

Keywords

Atherosclerosis
Global Health
Heart Defects, Congenital
Humans
Prevalence
Journal Article
Review

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10.1136/heartjnl-2016-311012

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title = "Cyanotic congenital heart disease and atherosclerosis",

abstract = "Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.",

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doi = "10.1136/heartjnl-2016-311012",

language = "English",

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journal = "Heart",

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T1 - Cyanotic congenital heart disease and atherosclerosis

AU - Tarp, Julie Bjerre

AU - Jensen, Annette Schophuus

AU - Engstrøm, Thomas

AU - Holstein-Rathlou, Niels-Henrik

AU - Søndergaard, Lars

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.

AB - Improved treatment options in paediatric cardiology and congenital heart surgery have resulted in an ageing population of patients with cyanotic congenital heart disease (CCHD). The risk of acquired heart disease such as atherosclerosis increases with age.Previous studies have speculated whether patients with CCHD are protected against atherosclerosis. Results have shown that the coronary arteries of patients with CCHD are free from plaques and stenosis. Decreased carotid intima-media thickness and low total plasma cholesterol may indicate a reduced risk of later development of atherosclerosis. However, the evidence is still sparse and questionable, and a reasonable explanation for the decreased risk of developing atherosclerosis in patients with CCHD is still missing.This review provides an overview of what is known about the prevalence and potential causes of the reduced risk of atherosclerosis in patients with CCHD.

KW - Atherosclerosis

KW - Global Health

KW - Heart Defects, Congenital

KW - Humans

KW - Prevalence

KW - Journal Article

KW - Review

U2 - 10.1136/heartjnl-2016-311012

DO - 10.1136/heartjnl-2016-311012

M3 - Review

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SN - 1355-6037

VL - 103

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JO - Heart

JF - Heart

ER -

Cyanotic congenital heart disease and atherosclerosis

Abstract

Keywords

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