Customizing laboratory mice by modifying gut microbiota and host immunity in an early "window of opportunity".

TY - JOUR

T1 - Customizing laboratory mice by modifying gut microbiota and host immunity in an early "window of opportunity".

AU - Hansen, Camilla Hartmann Friis

AU - Metzdorff, Stine Broeng

AU - Hansen, Axel Jacob Kornerup

PY - 2013

Y1 - 2013

N2 - We recently investigated how postnatal microbial gut colonization is important for the development of the immune system, especially in the systemic compartments. This addendum presents additional data which in accordance with our previous findings show that early life microbial colonization is critical for a fine-tuned immune homeostasis to develop also in the intestinal environment. A generalized reduction in the expression of immune signaling related genes in the small intestine may explain previously shown increased systemic adaptive immune reactivity, if the regulatory cross-talk between intra- and extra-intestinal immune cells is immature following a neonatal germ-free period. These findings are furthermore discussed in the context of recently published results on how lack of microbial exposure in the neonatal life modifies disease expression in rodents used as models mimicking human inflammatory diseases. In particular, with a focus on how these interesting findings could be used to optimize the use of rodent models.

AB - We recently investigated how postnatal microbial gut colonization is important for the development of the immune system, especially in the systemic compartments. This addendum presents additional data which in accordance with our previous findings show that early life microbial colonization is critical for a fine-tuned immune homeostasis to develop also in the intestinal environment. A generalized reduction in the expression of immune signaling related genes in the small intestine may explain previously shown increased systemic adaptive immune reactivity, if the regulatory cross-talk between intra- and extra-intestinal immune cells is immature following a neonatal germ-free period. These findings are furthermore discussed in the context of recently published results on how lack of microbial exposure in the neonatal life modifies disease expression in rodents used as models mimicking human inflammatory diseases. In particular, with a focus on how these interesting findings could be used to optimize the use of rodent models.

KW - Faculty of Health and Medical Sciences

U2 - 10.4161/gmic.23999

DO - 10.4161/gmic.23999

M3 - Journal article

C2 - 23549457

SN - 1949-0976

VL - 4

SP - 241

EP - 245

JO - Gut Microbes

JF - Gut Microbes

IS - 3

ER -